With reference to antibiotic resistance all of the following statements are true except -

• A. The most common mechanism is production of neutralizing enzymes by bacteria
• B. Plasmid mediated resistance is exclusively transferred vertically
• C. Complete elimination of target is the mechanism by which enterococci develop resistance to vancomycin
• D. Alteration of target lesions leads to development of resistance to antibiotics in Streptococcus pneumoniae