Which of the given statements is incorrect about Searching for orthologs to a protein family in an EST database?

ESTs with a high percent identity with the query sequence, a long alignment with the query sequence, and a very low E value of the alignment score represent groups of paralogous and orthologous genes

Searches of EST databases for matches to a query sequence routinely produce minimal amounts of output that must be searched manually for significant hits

To identify orthologs as the most closely related sequence, ESTs were aligned using the amino acid alignment as a guide

To identify orthologs as the most closely related sequence, a phylogenetic tree was produced by the maximum likelihood method

Which of the given statements is incorrect about Searching for ortholo

1.	Which of the given statements is incorrect about Searching for orthologs to a protein family in an EST database?
A.	Searches of EST databases for matches to a query sequence routinely produce minimal amounts of output that must be searched manually for significant hits
B.	ESTs with a high percent identity with the query sequence, a long alignment with the query sequence, and a very low E value of the alignment score represent groups of paralogous and orthologous genes
C.	To identify orthologs as the most closely related sequence, ESTs were aligned using the amino acid alignment as a guide
D.	To identify orthologs as the most closely related sequence, a phylogenetic tree was produced by the maximum likelihood method
Answer» B. ESTs with a high percent identity with the query sequence, a long alignment with the query sequence, and a very low E value of the alignment score represent groups of paralogous and orthologous genes

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