Which of the following statement is not true about NSAIDSs ?

• A. Acetyl salicylic acid is an irreversible inhibitor of COX enzyme
• B. Salicylic acid reduces in vivo synthesis of prostaglandins
• C. Duration of action of aspirin in primarily related to the pharmocokinetic clearence of the drug from the body
• D. Antiplatelet effect of low-dose aspirin is related to COX inhibition