Which of the following is untrue regarding the predicting Interactions Based on Phylogenetic Information?

• A. Proteins do not operate as a complex
• B. This method detects the co-presence or co-absence of orthologs across a number of genomes
• C. Protein interactions can be predicted using phylogenetic profiles
• D. Phylogenetic profile are defined as patterns of gene pairs that are concurrently present or absent across genomes