Which of the following is untrue about Expression Profiling–Based Method?

• A. Genes with similar expression profiles are considered coexpressed, which can be identified through a clustering approach
• B. This approach appears to be less effective for finding transcription factor binding sites
• C. An advanced alignment-independent profile construction method such as EM and Gibbs motif sampling is often used in finding the subtle sequence motifs
• D. The basis for coexpression is thought to be due to common promoters and regulatory elements