Which of the following is not an advantage of Needleman-Wunsch algorithm?

• A. New algorithmic improvements as well as increasing computer capacity make it possible to align a query sequence against a large DB in a few minutes
• B. Similar sequence region is of same order and orientation
• C. This does not help in determining evolutionary relationship
• D. If you have 2 genes that are already understood as closely related, then this type of algorithm can be used to understand them in further details