Which of the following is incorrect regarding the Protein Identification through Database Searching?

• A. MS characterization of proteins is highly dependent on bioinformatic analysis
• B. Bioinformatics programs can be used to search for the identity of a protein in a database of theoretically digested proteins
• C. Even in reality, the protease digestion is always perfect in MS
• D. The purpose of the database search is to find exact or nearly exact matches