Which of the following is incorrect about Purification of protein complexes followed by mass spectrometry?

• A. Isolating protein complexes from cells allows identification of interactions between ensembles of proteins instead of just pairs
• B. Systematic purification of complexes on a large scale is done by tagging hundreds of genes with an epitope
• C. UnLike in the yeast-two-hybrid assay, this does not involve chimeric genes
• D. Affinity purification based on the epitope will then extract all the proteins attached to the bait protein from cell lysates