If hybridization is carried out with a clone having a sequence similar to that of the vector from which library has been constructed, then it is of no use. Choose the correct statement in respect to it.

• A. PCR amplification of the probe can be carried out
• B. Excision of the probe should be carried out which should be followed polyacrylamide gel electrophoresis
• C. If the vector sequence and the DNA probe are having similarities, some of the vector would be hybridized
• D. Probe should be in a vector that is having some sequence similarity with the library to be screened