Diuretics acting on the ascending limb of loop of Henle are the most efficacious in promoting salt and water excretion because:

• A. Maximum percentage of salt and water is reabsorbed in this segment
• B. Reabsorptive capacity of the segments distal to it is limited
• C. This segment is highly permeable to both salt and water
• D. This segment is responsible for creating corticomedullary osmotic gradient