54 + Mcqs in Biopharmaceutics and Pharmacokinetics Page 1 McqOptions

1.	The process by which molecules diffuse from a region of higher concentration to a region of lower concentration and no external energy is expended is called
A.	Passive diffusion
B.	Active transport
C.	Pore transport
D.	Facilitation diffusion
Answer» B. Active transport

Discussion

2.	Which law states that 'the rate of diffusion is proportional to both the surface area and concentration difference and is inversely proportional to the thickness of the membrane ?
A.	Fick's Law
B.	Avagadro's Law
C.	Hooke's Law
D.	Pascal's Law
Answer» B. Avagadro's Law

Discussion

3.	Which of the following is alimentary route of administration when passage of drug through liver is minimized?
A.	Oral
B.	Transdermal
C.	Rectal
D.	Intraduodenal
Answer» D. Intraduodenal

Discussion

4.	is the process of movement of unchanged drug from the site of administration to the systemic circulation.
A.	Absorption
B.	Dissolution
C.	Distribution
D.	Elimination
Answer» B. Dissolution

Discussion

5.	The occurrence of food in the GI tract can affect the drug bioavailability from an oral drug product. The above give statement is?
A.	True
B.	False
C.	Both of the above
D.	None of the above
Answer» B. False

Discussion

6.	The deleterious effect of various coatings on drug dissolution is shown in orders below. Which one of them is the correct order?
A.	Enteric coat > sugar coat > nonenteric film coat
B.	Enteric coat > nonenteric film coat > sugar coat
C.	Nonenteric film coat > sugar coat > enteric coat
D.	Sugar coat > enteric coat > nonenteric film coat
Answer» B. Enteric coat > nonenteric film coat > sugar coat

Discussion

7.	According to the pH-partition hypothesis which one of the given options doesn t govern the absorption?
A.	The molecular size of the drug
B.	PH at the absorption site
C.	Lipid solubility of unionized drugs
D.	Dissociation constant
Answer» B. PH at the absorption site

Discussion

8.	If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.
A.	True
B.	False
C.	none
D.	all
Answer» C. none

Discussion

9.	Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.
A.	True
B.	False
C.	none
D.	all
Answer» B. False

Discussion

10.	In vitro determination of bioavailability by dissolution rate is not the best way to determine therapeutic efficacy.
A.	True
B.	False
C.	none
D.	all
Answer» C. none

Discussion

11.	Vehicles are the solvent system for the liquefied drug. Which one of them is not an example of a kind of vehicle?
A.	Aqueous vehicle
B.	Non-aqueous water-miscible vehicles
C.	Non-aqueous water immiscible vehicles
D.	A salt solution of the drug
Answer» E.

Discussion

12.	In the sequence of events in the drug absorption from orally administered solid dosage, which one comes at first?
A.	Disintegration
B.	Disaggregation
C.	Dissolution
D.	Absorption
Answer» B. Disaggregation

Discussion

13.	If the bioavailability of test formulation is 80-120% of the reference standard, it is considered to be bioequivalent.
A.	True
B.	False
C.	none
D.	all
Answer» B. False

Discussion

14.	What are the major stability problems which result in poor bioavailability of any orally administered drugs?
A.	Acidic degradation
B.	Degradation by salivary amylase
C.	Degradation of the drug in inactive form
D.	Interaction with the excipients and degradation in an inactive form
Answer» E.

Discussion

15.	For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems?
A.	0.9%
B.	1%
C.	2%
D.	0.11%
Answer» C. 2%

Discussion

16.	The urinary excretion of the unchanged drug is directly proportional to the plasma concentration of a drug.
A.	True
B.	False
C.	none
D.	all
Answer» B. False

Discussion

17.	If the steady-state plasma concentration is directly proportional to the dose, then .in the kinetics exists.
A.	Linearity
B.	Non-linearity
C.	Both of the above
D.	None of the above
Answer» B. Non-linearity

Discussion

18.	What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?
A.	148.80ml2/ng min
B.	150ml2/ng min
C.	152ml2/ng min
D.	140ml2/ng min
Answer» B. 150ml2/ng min

Discussion

19.	What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance of creatinine is 95ml/min?
A.	0.421
B.	2.38
C.	0.010
D.	0.025
Answer» B. 2.38

Discussion

20.	The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.
A.	True
B.	False
C.	none
D.	all
Answer» B. False

Discussion

21.	The agglomerative phase of the communication method grinds the drug in a ball mill for a long time to affect spontaneous agglomeration. But results showed tablets produced are softer.
A.	True
B.	False
C.	none
D.	all
Answer» C. none

Discussion

22.	The half life of a drug eliminated by first order elimination kinetics will be longer in individuals who have an:
A.	increased volume of distribution or increased clearance
B.	increased volume of distribution or decreased clearance
C.	decreased volume of distribution or increased clearance
D.	decreased volume of distribution or decreased clearance
Answer» C. decreased volume of distribution or increased clearance

Discussion

23.	Following is the order in decreasing order of drug binding to the extravascular tissue. Which one is the correct order?
A.	Liver > kidney > muscle > lung
B.	Liver > muscle > lung > kidney
C.	Liver > muscle > kidney > lung
D.	Liver > kidney > lung > muscle
Answer» E.

Discussion

24.	composed of groups of tissues with lower blood perfusion and different affinity the drug with slow drug distribution.
A.	Central compartment
B.	Peripheral compartment
C.	Both of the above
D.	None of the above
Answer» C. Both of the above

Discussion

25.	Up to how much the microvilli in the small intestine increases the relative surface area of the small intestine?
A.	3 times
B.	30 times
C.	100 times
D.	600 times
Answer» E.

Discussion

26.	Capsules with bigger particles and intense packing have poor drug release and dissolution rate due to an increase in the pore size.
A.	True
B.	False
C.	none
D.	all
Answer» C. none

Discussion

27.	Drugs in patients with renal impairment have same pharmacokinetic profile as in a person without renal failure.
A.	True
B.	False
C.	none
D.	all
Answer» C. none

Discussion

28.	is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose.
A.	Primary Dose
B.	Initial Dose
C.	Loading dose
D.	None of the above
Answer» D. None of the above

Discussion

29.	Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.
A.	True
B.	False
C.	none
D.	all
Answer» B. False

Discussion

30.	The phenomenon of decreased drug metabolizing ability of the enzymes by drugs is known as
A.	enzyme induction
B.	enzyme inhibition
C.	both (a) & (b)
D.	None of the above
Answer» C. both (a) & (b)

Discussion

31.	Which of the following decreasing order of blood flow rate through the muscular tissue is in the right order?
A.	Arm > thigh > buttocks
B.	Arm > buttocks > thigh
C.	Buttocks > thigh > arm
D.	Thigh > arm > buttocks
Answer» B. Arm > buttocks > thigh

Discussion

32.	In cell membrane the hydrocarbon chains for hydrophilic phase and the polar heads form hydrophobic phase.
A.	True
B.	False
C.	none
D.	all
Answer» C. none

Discussion

33.	The volume of plasma needed each minute to supply a substance at the rate at which it is excreted in the urine is known as the
A.	diffusion constant of the substance
B.	clearance of the substance
C.	extraction ratio of the substance
D.	filtration rate of the substance
Answer» C. extraction ratio of the substance

Discussion

34.	Compounds excreted in bile is classified into 3 categories. Which one of the following does not come under the categories?
A.	Drugs with bile/plasma concentration ratio approximately 1
B.	Drugs with bile/plasma concentration ratio between 10-1000
C.	Drugs with bile/plasma concentration ratio of less than 1
D.	Drugs with bile/plasma concentration ratio above 1000
Answer» E.

Discussion

35.	.. is a mathematical concept which describes a space in the body which a drug appears to occupy.
A.	Order of reaction
B.	Compartment
C.	Distribution
D.	Elimination
Answer» C. Distribution

Discussion

36.	...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid and uniform drug distribution.
A.	Central compartment
B.	Peripheral compartment
C.	both of the above
D.	None of the above
Answer» B. Peripheral compartment

Discussion

37.	In meningitis and encephalitis polar antibiotics gain access to BBB which don t happen to a healthy person.
A.	True
B.	False
C.	none
D.	all
Answer» B. False

Discussion

38.	The compartment models provide visual representation of various rate processes involved in drug disposition. Given statement is:
A.	False
B.	True
C.	Cannot say
D.	None of the above
Answer» C. Cannot say

Discussion

39.	A multicompartment model assumes that all transfer rate processes for the passage of drug into or out of individual compartments are .. processes.
A.	First-order
B.	Second order
C.	Pseudo order
D.	None of the above
Answer» B. Second order

Discussion

40.	It is defined as the distribution of a drug between plasma and the rest of the body after oral or parenteral dosing.
A.	Volume of distribution (VD)
B.	Apparent volume of drug distribution
C.	Phagocytosis
D.	None of the above
Answer» C. Phagocytosis

Discussion

41.	A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate of blood flow to the liver would be
A.	60 milliliters/min
B.	120 milliliters/min
C.	650 milliliters/min
D.	1500 milliliters/min
Answer» E.

Discussion

42.	Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell?
A.	Polar head
B.	Hydrophobic head
C.	Hydrophobic core
D.	Non polar head
Answer» D. Non polar head

Discussion

43.	it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.
A.	Accumulation Index
B.	Apparent volume of drug distribution
C.	Accumulation factor
D.	None of the above
Answer» B. Apparent volume of drug distribution

Discussion

44.	..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.
A.	Accumulation Index
B.	Apparent volume of drug distribution
C.	Accumulation factor
D.	None of the above
Answer» B. Apparent volume of drug distribution

Discussion

45.	The mathematical relationship between plasma drug concentration and pharmacological response is called as ..
A.	PK modeling
B.	PD modeling
C.	PK-PD modeling
D.	None of the above
Answer» D. None of the above

Discussion

46.	For a drug that is eliminated primarily by renal glomerular filtration, the theoretical maximum clearance is approximately
A.	1-2 milliliters/min
B.	12 milliliters/min
C.	120 milliliters/min
D.	1200 milliliters/min
Answer» D. 1200 milliliters/min

Discussion

47.	The rate of drug transport across a cell membrane by lipid diffusion depends on all of the following except
A.	Drug size (diffusion constant)
B.	Surface area of absorption
C.	Lipid partition coefficient
D.	Density of tr
Answer» B. Surface area of absorption

Discussion

48.	Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.
A.	True
B.	False
C.	none
D.	all
Answer» C. none

Discussion

49.	If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the given statement is true?
A.	Apparent volume of distribution of drug X decrease
B.	Free concentration of drug X in blood will be increase
C.	Apparent volume of distribution of drug Y decrease
D.	Toxicity of drug Y increase
Answer» C. Apparent volume of distribution of drug Y decrease

Discussion

50.	The drug concentration between Minimum Effective Concentration and Maximum Safe Concentration is called
A.	Therapeutic range
B.	Area under curve
C.	Peak response
D.	Pharmacological response
Answer» B. Area under curve

Discussion

Explore topic-wise MCQs in Bachelor of Pharmacy (BDot Pharma).

The process by which molecules diffuse from a region of higher concentration to a region of lower concentration and no external energy is expended is called

Which law states that 'the rate of diffusion is proportional to both the surface area and concentration difference and is inversely proportional to the thickness of the membrane ?

Which of the following is alimentary route of administration when passage of drug through liver is minimized?

is the process of movement of unchanged drug from the site of administration to the systemic circulation.

The occurrence of food in the GI tract can affect the drug bioavailability from an oral drug product. The above give statement is?

The deleterious effect of various coatings on drug dissolution is shown in orders below. Which one of them is the correct order?

According to the pH-partition hypothesis which one of the given options doesn t govern the absorption?

If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.

Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.

In vitro determination of bioavailability by dissolution rate is not the best way to determine therapeutic efficacy.

Vehicles are the solvent system for the liquefied drug. Which one of them is not an example of a kind of vehicle?

In the sequence of events in the drug absorption from orally administered solid dosage, which one comes at first?

If the bioavailability of test formulation is 80-120% of the reference standard, it is considered to be bioequivalent.

What are the major stability problems which result in poor bioavailability of any orally administered drugs?

For oral formulation, what should be the minimum aqueous solubility to avoid bioavailability problems?

The urinary excretion of the unchanged drug is directly proportional to the plasma concentration of a drug.

If the steady-state plasma concentration is directly proportional to the dose, then .in the kinetics exists.

What will be the renal clearance if the rate of urinary excretion is 625 ml/min and plasma drug concentration is 4.2 ng/ml?

What will be the renal clearance ratio of a drug whose renal clearance is 40ml/min and the clearance of creatinine is 95ml/min?

The renal clearance of a drug bound to plasma protein is increased after displacement with another drug.

The agglomerative phase of the communication method grinds the drug in a ball mill for a long time to affect spontaneous agglomeration. But results showed tablets produced are softer.

The half life of a drug eliminated by first order elimination kinetics will be longer in individuals who have an:

Following is the order in decreasing order of drug binding to the extravascular tissue. Which one is the correct order?

composed of groups of tissues with lower blood perfusion and different affinity the drug with slow drug distribution.

Up to how much the microvilli in the small intestine increases the relative surface area of the small intestine?

Capsules with bigger particles and intense packing have poor drug release and dissolution rate due to an increase in the pore size.

Drugs in patients with renal impairment have same pharmacokinetic profile as in a person without renal failure.

is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose.

Any changes in fraction bioavailable, elimination half-life indicates nonlinearity of that particular drug.

The phenomenon of decreased drug metabolizing ability of the enzymes by drugs is known as

Which of the following decreasing order of blood flow rate through the muscular tissue is in the right order?

In cell membrane the hydrocarbon chains for hydrophilic phase and the polar heads form hydrophobic phase.

The volume of plasma needed each minute to supply a substance at the rate at which it is excreted in the urine is known as the

Compounds excreted in bile is classified into 3 categories. Which one of the following does not come under the categories?

.. is a mathematical concept which describes a space in the body which a drug appears to occupy.

...................is composed of highly perfused tissues, extracellular fluid, and blood with rapid and uniform drug distribution.

In meningitis and encephalitis polar antibiotics gain access to BBB which don t happen to a healthy person.

The compartment models provide visual representation of various rate processes involved in drug disposition. Given statement is:

A multicompartment model assumes that all transfer rate processes for the passage of drug into or out of individual compartments are .. processes.

It is defined as the distribution of a drug between plasma and the rest of the body after oral or parenteral dosing.

A Normal sized adult having hepatic clearance of a drug whose metabolism is limited by the rate of blood flow to the liver would be

Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell?

it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.

..it is the extent to which a drug will accumulate relative to the first dose can be quantified by an accumulation factor R.

The mathematical relationship between plasma drug concentration and pharmacological response is called as ..

For a drug that is eliminated primarily by renal glomerular filtration, the theoretical maximum clearance is approximately

The rate of drug transport across a cell membrane by lipid diffusion depends on all of the following except

Drug having a small partition coefficient can rapidly penetrate the lipid membrane but diffusion through the unstirred water layer is a rate-limiting step.

If the drug Y bind with plasma albumin with 10 times more affinity than drug X. Which the given statement is true?

The drug concentration between Minimum Effective Concentration and Maximum Safe Concentration is called