Despite their short half lives(2 hours), Proton pumps Inhibitors(PPIs) cause a prolonged suppression of acid secretion(up to 48 hours) because -

• A. They are prodrugs and undergo activation gradually
• B. They exit from the plasma and enter acid secretory canaliculi and stay here, blocking the secretion of acid for a long time
• C. They irreversibly inhibit the proton pump molecule and hence, acid secretion requires synthesis of new proton pumps
• D. They are avilable as enteric coated capsules, from which drug is gradually released