A patient who is being treated for temporal lobe epilepsy(complex partial seizures)and who is having recurrent seizures on his chronic regimen of carbamazepine is given phenobarbital as a second drug.However,the seizures increase in frequency.What is the probable reason for the apparent deleterious effect of adding phenobarbital:

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TuteeHUB · Accepted Answer

Decreased stability of CNS neuronal membranes

TuteeHUB · Answer

Intracerebral bleeding from worsening bone marrow supression

TuteeHUB · Answer

Decreased carbamazepine level

TuteeHUB · Answer

Hypokalemia

1.	A patient who is being treated for temporal lobe epilepsy(complex partial seizures)and who is having recurrent seizures on his chronic regimen of carbamazepine is given phenobarbital as a second drug.However,the seizures increase in frequency.What is the probable reason for the apparent deleterious effect of adding phenobarbital:
A.	Intracerebral bleeding from worsening bone marrow supression
B.	Decreased carbamazepine level
C.	Decreased stability of CNS neuronal membranes
D.	Hypokalemia
Answer» C. Decreased stability of CNS neuronal membranes

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