MCQOPTIONS
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MCQOPTIONS
This section includes 13 Mcqs, each offering curated multiple-choice questions to sharpen your Cytogenetics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
In presence of Thyroid hormone the receptor TR binds to ____________ |
| A. | RXR directly |
| B. | mRPD3 directly |
| C. | NcoR directly |
| D. | mRPD3 indirectly |
| Answer» B. mRPD3 directly | |
| 2. |
In an experiment you perform the following- you attach a flag epitope to HDAC, you over express a mutated Mad1-pro gene within the experimental cell, you immunoprecipitate the protein complex using flag epitope and run that on a non-denaturing SDS PAGE and western blot. Now you add antibodies for HDAC, MAD1 and SIN3A stripping after each addition. What will you observe? |
| A. | Bands at same position every time |
| B. | 3 bands at different positions one at a time |
| C. | Bands at same position on 2 occasions |
| D. | No band |
| Answer» D. No band | |
| 3. |
In a substrate X catabolic gene promoter you replace the normal histones by your experimental histones – ones with arginine side chains in place of histidine. What will be the effect on the concentration of substrate X against the control? |
| A. | Concentration will increase |
| B. | Concentration will decrease |
| C. | Concentration will remain constant |
| D. | Concentration will fluctuate and no definite result will be obtained |
| Answer» D. Concentration will fluctuate and no definite result will be obtained | |
| 4. |
IN_AN_EXPERIMENT_YOU_PERFORM_THE_FOLLOWING-_YOU_ATTACH_A_FLAG_EPITOPE_TO_HDAC,_YOU_OVER_EXPRESS_A_MUTATED_MAD1-PRO_GENE_WITHIN_THE_EXPERIMENTAL_CELL,_YOU_IMMUNOPRECIPITATE_THE_PROTEIN_COMPLEX_USING_FLAG_EPITOPE_AND_RUN_THAT_ON_A_NON-DENATURING_SDS_PAGE_AND_WESTERN_BLOT._NOW_YOU_ADD_ANTIBODIES_FOR_HDAC,_MAD1_AND_SIN3A_STRIPPING_AFTER_EACH_ADDITION._WHAT_WILL_YOU_OBSERVE??$ |
| A. | Bands at same position every time |
| B. | 3 bands at different positions one at a time |
| C. | Bands at same position on 2 occasions |
| D. | No band |
| Answer» D. No band | |
| 5. |
In_presence_of_Thyroid_hormone_the_receptor_TR_binds_to_____________$ |
| A. | RXR directly |
| B. | mRPD3 directly |
| C. | NcoR directly |
| D. | mRPD3 indirectly |
| Answer» B. mRPD3 directly | |
| 6. |
Which of the following association acts as transcriptional activator? |
| A. | Myc- Max |
| B. | Mad- Max |
| C. | Map- Mad |
| D. | MapK- Myc |
| Answer» B. Mad- Max | |
| 7. |
Which of the following is not a common mode of histone modification in eukaryotes? |
| A. | Methylation |
| B. | Phosphortlation |
| C. | Sulphonation |
| D. | Ubiquitinylation |
| Answer» D. Ubiquitinylation | |
| 8. |
You take a crude cell lysate and treat it with DNase. Now wash it and add protease. Use specific restriction endonuclease to get your desired fragment and run it on a gel. You see a single band. Which of the following will be true about the fragment? |
| A. | It is actively transcribed |
| B. | Only part of it is transcribed |
| C. | No part of it transcribed |
| D. | Undefined transcriptional nature |
| Answer» D. Undefined transcriptional nature | |
| 9. |
In a substrate X catabolic gene promoter you replace the normal histones by your experimental histones – ones with arginine side chains in place of histidine. What will be the effect on the concentration of substrate X against the control?$ |
| A. | Concentration will increase |
| B. | Concentration will decrease |
| C. | Concentration will remain constant |
| D. | Concentration will fluctuate and no definite result will be obtained |
| Answer» D. Concentration will fluctuate and no definite result will be obtained | |
| 10. |
Which histone(s) are acted upon by HAT? |
| A. | H1, H2 |
| B. | H3 |
| C. | H2A, H2B |
| D. | H3, H4 |
| Answer» E. | |
| 11. |
Which of the following will increase transcription? |
| A. | Shielding positive charge of DNA |
| B. | Shielding positive charge of histones |
| C. | Shielding promoter for polymerase binding |
| D. | Shielding termination region |
| Answer» D. Shielding termination region | |
| 12. |
Histones are __________ |
| A. | Neutral |
| B. | Positively charged |
| C. | Negatively charged |
| D. | Neutral with positive and negative domains |
| Answer» C. Negatively charged | |
| 13. |
In which of the following chromosome compaction is absent? |
| A. | Cellulomonas flavigena |
| B. | Allium sativum |
| C. | Panthera tigris |
| D. | Saccharomyces cerevisiae |
| Answer» B. Allium sativum | |