Explore topic-wise MCQs in Cytogenetics.

This section includes 20 Mcqs, each offering curated multiple-choice questions to sharpen your Cytogenetics knowledge and support exam preparation. Choose a topic below to get started.

1.

In Angelman syndrome we don’t see___________

A. Microcephaly
B. Speech impairment
C. Overeating urge
D. Unprovoked laughter
Answer» D. Unprovoked laughter
2.

What will happen if an individual receives two copies of a gene from the same parent?

A. UPD
B. One gene will be automatically inactivated
C. Both the genes will show their product
D. Nothing much will be seen
Answer» B. One gene will be automatically inactivated
3.

During _________________ both the H19 alleles are ___________________

A. Oogenesis, inactivated
B. Oogenesis, activated
C. Oogenesis, hyper-activated
D. Spermatogenesis, activated
Answer» C. Oogenesis, hyper-activated
4.

In mice the expression of Igf2 and H199 is only controlled by methylation.

A. True
B. False
Answer» C.
5.

Which of the following doesn’t agree with XIST?

A. It codes for an mRNA that coats the inactive X chromosome into a bar body
B. It is the only gene that is active in inactive X chromosome
C. The embryo cells shows that maternal allele XIST is active over paternal
D. Inactivation is seen in somatic cells
Answer» D. Inactivation is seen in somatic cells
6.

CHOOSE_THE_WRONG_STATEMENT_FROM_THE_FOLLOWING.?$

A. Maternal Igf2 is methylated to prevent expression
B. Paternal H19 is methylated to avoid expression
C. The enhancer can lead to expression of H19 in maternal gene
D. The enhancer can’t lead to expression of Igf2 in paternal gene
Answer» B. Paternal H19 is methylated to avoid expression
7.

IN_MICE_THE_EXPRESSION_OF_IGF2_AND_H199_IS_ONLY_CONTROLLED_BY_METHYLATION.?$

A. True
B. False
Answer» C.
8.

What will happen if an individual receives two copies of a gene from the same parent?$

A. UPD
B. One gene will be automatically inactivated
C. Both the genes will show their product
D. Nothing much will be seen
Answer» B. One gene will be automatically inactivated
9.

During _________________ both the H19 alleles are ___________________$

A. Oogenesis, inactivated
B. Oogenesis, activated
C. Oogenesis, hyper-activated
D. Spermatogenesis, activated
Answer» C. Oogenesis, hyper-activated
10.

In Angelman syndrome we don’t see___________$

A. Microcephaly
B. Speech impairment
C. Overeating urge
D. Unprovoked laughter
Answer» D. Unprovoked laughter
11.

When the specific non-imprint gene from the chromosome 15 of the mother s missing it leads to _________________

A. Pader Willi syndrome
B. Angelman syndrome
C. Down’s syndrome
D. Klinefelter syndrome
Answer» C. Down‚Äö√Ñ√∂‚àö√ë‚àö¬•s syndrome
12.

Which of the following is incorrect for Pader will syndrome?

A. This is due to failure of inheritance of several non-imprint genes
B. It is seen for chromosome 15
C. It causes loss of active genes in 15q11-q13
D. It occurs when the region containing specific genes in the maternal chromosome are missing
Answer» E.
13.

In mice H19 and Igf2 genes are controlled by the same enhancer. Which of the following is true?

A. The enhancer enhances both the gene on promoter binding
B. In one chromosome both the genes are expressed and in other they are not
C. Igf2 shows paternal imprinting, H19 shows maternal imprinting
D. Both the genes show paternal imprinting
Answer» D. Both the genes show paternal imprinting
14.

In mice if you delete the Igf2 gene from a female, the progeny will_____________

A. Be smaller
B. Die
C. No major change
D. Be larger
Answer» D. Be larger
15.

Choose the wrong statement in the regulation of imprinting.

A. Methylation of the C residues are seen in the CpG islands
B. The methylation prevents binding of the RNA polymerase
C. Genes are methylated at random
D. Deletion of gene with methylated CpG islands will have no effect
Answer» D. Deletion of gene with methylated CpG islands will have no effect
16.

The imprinting of genes has an epigenetic mode of regulation.

A. True
B. False
Answer» B. False
17.

Which of the following doesn’t agree with XIST?$

A. It codes for an mRNA that coats the inactive X chromosome into a bar body
B. It is the only gene that is active in inactive X chromosome
C. The embryo cells shows that maternal allele XIST is active over paternal
D. Inactivation is seen in somatic cells
Answer» D. Inactivation is seen in somatic cells
18.

In Igf2 of human ______________ allele is expressed, and Igfr of mice __________ allele is expressed.

A. Maternal, maternal
B. Paternal, paternal
C. Maternal, paternal
D. Paternal, maternal
Answer» E.
19.

Differential expression of the genetic material depending on its parentage of inheritance gives____________

A. Penetrance
B. Expressivity
C. Imprinting
D. Non-penetrance
Answer» D. Non-penetrance
20.

Genomic imprinting in autosomes is seen in _________________ percent of the genes.

A. 100%
B. 50%
C. 25%
D. <1%
Answer» E.