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This section includes 20 Mcqs, each offering curated multiple-choice questions to sharpen your Cytogenetics knowledge and support exam preparation. Choose a topic below to get started.
1. |
In Angelman syndrome we don’t see___________ |
A. | Microcephaly |
B. | Speech impairment |
C. | Overeating urge |
D. | Unprovoked laughter |
Answer» D. Unprovoked laughter | |
2. |
What will happen if an individual receives two copies of a gene from the same parent? |
A. | UPD |
B. | One gene will be automatically inactivated |
C. | Both the genes will show their product |
D. | Nothing much will be seen |
Answer» B. One gene will be automatically inactivated | |
3. |
During _________________ both the H19 alleles are ___________________ |
A. | Oogenesis, inactivated |
B. | Oogenesis, activated |
C. | Oogenesis, hyper-activated |
D. | Spermatogenesis, activated |
Answer» C. Oogenesis, hyper-activated | |
4. |
In mice the expression of Igf2 and H199 is only controlled by methylation. |
A. | True |
B. | False |
Answer» C. | |
5. |
Which of the following doesn’t agree with XIST? |
A. | It codes for an mRNA that coats the inactive X chromosome into a bar body |
B. | It is the only gene that is active in inactive X chromosome |
C. | The embryo cells shows that maternal allele XIST is active over paternal |
D. | Inactivation is seen in somatic cells |
Answer» D. Inactivation is seen in somatic cells | |
6. |
CHOOSE_THE_WRONG_STATEMENT_FROM_THE_FOLLOWING.?$ |
A. | Maternal Igf2 is methylated to prevent expression |
B. | Paternal H19 is methylated to avoid expression |
C. | The enhancer can lead to expression of H19 in maternal gene |
D. | The enhancer can’t lead to expression of Igf2 in paternal gene |
Answer» B. Paternal H19 is methylated to avoid expression | |
7. |
IN_MICE_THE_EXPRESSION_OF_IGF2_AND_H199_IS_ONLY_CONTROLLED_BY_METHYLATION.?$ |
A. | True |
B. | False |
Answer» C. | |
8. |
What will happen if an individual receives two copies of a gene from the same parent?$ |
A. | UPD |
B. | One gene will be automatically inactivated |
C. | Both the genes will show their product |
D. | Nothing much will be seen |
Answer» B. One gene will be automatically inactivated | |
9. |
During _________________ both the H19 alleles are ___________________$ |
A. | Oogenesis, inactivated |
B. | Oogenesis, activated |
C. | Oogenesis, hyper-activated |
D. | Spermatogenesis, activated |
Answer» C. Oogenesis, hyper-activated | |
10. |
In Angelman syndrome we don’t see___________$ |
A. | Microcephaly |
B. | Speech impairment |
C. | Overeating urge |
D. | Unprovoked laughter |
Answer» D. Unprovoked laughter | |
11. |
When the specific non-imprint gene from the chromosome 15 of the mother s missing it leads to _________________ |
A. | Pader Willi syndrome |
B. | Angelman syndrome |
C. | Down’s syndrome |
D. | Klinefelter syndrome |
Answer» C. Down‚Äö√Ñ√∂‚àö√ë‚àö¬•s syndrome | |
12. |
Which of the following is incorrect for Pader will syndrome? |
A. | This is due to failure of inheritance of several non-imprint genes |
B. | It is seen for chromosome 15 |
C. | It causes loss of active genes in 15q11-q13 |
D. | It occurs when the region containing specific genes in the maternal chromosome are missing |
Answer» E. | |
13. |
In mice H19 and Igf2 genes are controlled by the same enhancer. Which of the following is true? |
A. | The enhancer enhances both the gene on promoter binding |
B. | In one chromosome both the genes are expressed and in other they are not |
C. | Igf2 shows paternal imprinting, H19 shows maternal imprinting |
D. | Both the genes show paternal imprinting |
Answer» D. Both the genes show paternal imprinting | |
14. |
In mice if you delete the Igf2 gene from a female, the progeny will_____________ |
A. | Be smaller |
B. | Die |
C. | No major change |
D. | Be larger |
Answer» D. Be larger | |
15. |
Choose the wrong statement in the regulation of imprinting. |
A. | Methylation of the C residues are seen in the CpG islands |
B. | The methylation prevents binding of the RNA polymerase |
C. | Genes are methylated at random |
D. | Deletion of gene with methylated CpG islands will have no effect |
Answer» D. Deletion of gene with methylated CpG islands will have no effect | |
16. |
The imprinting of genes has an epigenetic mode of regulation. |
A. | True |
B. | False |
Answer» B. False | |
17. |
Which of the following doesn’t agree with XIST?$ |
A. | It codes for an mRNA that coats the inactive X chromosome into a bar body |
B. | It is the only gene that is active in inactive X chromosome |
C. | The embryo cells shows that maternal allele XIST is active over paternal |
D. | Inactivation is seen in somatic cells |
Answer» D. Inactivation is seen in somatic cells | |
18. |
In Igf2 of human ______________ allele is expressed, and Igfr of mice __________ allele is expressed. |
A. | Maternal, maternal |
B. | Paternal, paternal |
C. | Maternal, paternal |
D. | Paternal, maternal |
Answer» E. | |
19. |
Differential expression of the genetic material depending on its parentage of inheritance gives____________ |
A. | Penetrance |
B. | Expressivity |
C. | Imprinting |
D. | Non-penetrance |
Answer» D. Non-penetrance | |
20. |
Genomic imprinting in autosomes is seen in _________________ percent of the genes. |
A. | 100% |
B. | 50% |
C. | 25% |
D. | <1% |
Answer» E. | |