Regarding renal handling of chloride, which is INCORRECT?

• A. about 25% of filtered load is actively reabsorbed in thick ascending limb
• B. proximal tubular reabsorption is reciprocally related to bicarbonate reabsorption
• C. it is actively secreted in distal tubule
• D. two chloride per sodium are reabsorbed in thick ascending limb
• E. chloride-hydroxide antiport are present in the kidney