MCQOPTIONS
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MCQOPTIONS
This section includes 20 Mcqs, each offering curated multiple-choice questions to sharpen your Cytogenetics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
In Angelman syndrome we don’t see___________ |
| A. | Microcephaly |
| B. | Speech impairment |
| C. | Overeating urge |
| D. | Unprovoked laughter |
| Answer» D. Unprovoked laughter | |
| 2. |
What will happen if an individual receives two copies of a gene from the same parent? |
| A. | UPD |
| B. | One gene will be automatically inactivated |
| C. | Both the genes will show their product |
| D. | Nothing much will be seen |
| Answer» B. One gene will be automatically inactivated | |
| 3. |
During _________________ both the H19 alleles are ___________________ |
| A. | Oogenesis, inactivated |
| B. | Oogenesis, activated |
| C. | Oogenesis, hyper-activated |
| D. | Spermatogenesis, activated |
| Answer» C. Oogenesis, hyper-activated | |
| 4. |
In mice the expression of Igf2 and H199 is only controlled by methylation. |
| A. | True |
| B. | False |
| Answer» C. | |
| 5. |
Which of the following doesn’t agree with XIST? |
| A. | It codes for an mRNA that coats the inactive X chromosome into a bar body |
| B. | It is the only gene that is active in inactive X chromosome |
| C. | The embryo cells shows that maternal allele XIST is active over paternal |
| D. | Inactivation is seen in somatic cells |
| Answer» D. Inactivation is seen in somatic cells | |
| 6. |
CHOOSE_THE_WRONG_STATEMENT_FROM_THE_FOLLOWING.?$ |
| A. | Maternal Igf2 is methylated to prevent expression |
| B. | Paternal H19 is methylated to avoid expression |
| C. | The enhancer can lead to expression of H19 in maternal gene |
| D. | The enhancer can’t lead to expression of Igf2 in paternal gene |
| Answer» B. Paternal H19 is methylated to avoid expression | |
| 7. |
IN_MICE_THE_EXPRESSION_OF_IGF2_AND_H199_IS_ONLY_CONTROLLED_BY_METHYLATION.?$ |
| A. | True |
| B. | False |
| Answer» C. | |
| 8. |
What will happen if an individual receives two copies of a gene from the same parent?$ |
| A. | UPD |
| B. | One gene will be automatically inactivated |
| C. | Both the genes will show their product |
| D. | Nothing much will be seen |
| Answer» B. One gene will be automatically inactivated | |
| 9. |
During _________________ both the H19 alleles are ___________________$ |
| A. | Oogenesis, inactivated |
| B. | Oogenesis, activated |
| C. | Oogenesis, hyper-activated |
| D. | Spermatogenesis, activated |
| Answer» C. Oogenesis, hyper-activated | |
| 10. |
In Angelman syndrome we don’t see___________$ |
| A. | Microcephaly |
| B. | Speech impairment |
| C. | Overeating urge |
| D. | Unprovoked laughter |
| Answer» D. Unprovoked laughter | |
| 11. |
When the specific non-imprint gene from the chromosome 15 of the mother s missing it leads to _________________ |
| A. | Pader Willi syndrome |
| B. | Angelman syndrome |
| C. | Down’s syndrome |
| D. | Klinefelter syndrome |
| Answer» C. Down‚Äö√Ñ√∂‚àö√ë‚àö¬•s syndrome | |
| 12. |
Which of the following is incorrect for Pader will syndrome? |
| A. | This is due to failure of inheritance of several non-imprint genes |
| B. | It is seen for chromosome 15 |
| C. | It causes loss of active genes in 15q11-q13 |
| D. | It occurs when the region containing specific genes in the maternal chromosome are missing |
| Answer» E. | |
| 13. |
In mice H19 and Igf2 genes are controlled by the same enhancer. Which of the following is true? |
| A. | The enhancer enhances both the gene on promoter binding |
| B. | In one chromosome both the genes are expressed and in other they are not |
| C. | Igf2 shows paternal imprinting, H19 shows maternal imprinting |
| D. | Both the genes show paternal imprinting |
| Answer» D. Both the genes show paternal imprinting | |
| 14. |
In mice if you delete the Igf2 gene from a female, the progeny will_____________ |
| A. | Be smaller |
| B. | Die |
| C. | No major change |
| D. | Be larger |
| Answer» D. Be larger | |
| 15. |
Choose the wrong statement in the regulation of imprinting. |
| A. | Methylation of the C residues are seen in the CpG islands |
| B. | The methylation prevents binding of the RNA polymerase |
| C. | Genes are methylated at random |
| D. | Deletion of gene with methylated CpG islands will have no effect |
| Answer» D. Deletion of gene with methylated CpG islands will have no effect | |
| 16. |
The imprinting of genes has an epigenetic mode of regulation. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 17. |
Which of the following doesn’t agree with XIST?$ |
| A. | It codes for an mRNA that coats the inactive X chromosome into a bar body |
| B. | It is the only gene that is active in inactive X chromosome |
| C. | The embryo cells shows that maternal allele XIST is active over paternal |
| D. | Inactivation is seen in somatic cells |
| Answer» D. Inactivation is seen in somatic cells | |
| 18. |
In Igf2 of human ______________ allele is expressed, and Igfr of mice __________ allele is expressed. |
| A. | Maternal, maternal |
| B. | Paternal, paternal |
| C. | Maternal, paternal |
| D. | Paternal, maternal |
| Answer» E. | |
| 19. |
Differential expression of the genetic material depending on its parentage of inheritance gives____________ |
| A. | Penetrance |
| B. | Expressivity |
| C. | Imprinting |
| D. | Non-penetrance |
| Answer» D. Non-penetrance | |
| 20. |
Genomic imprinting in autosomes is seen in _________________ percent of the genes. |
| A. | 100% |
| B. | 50% |
| C. | 25% |
| D. | <1% |
| Answer» E. | |