MCQOPTIONS
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MCQOPTIONS
This section includes 14 Mcqs, each offering curated multiple-choice questions to sharpen your Cytogenetics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the following is not a sensor of DSB? |
| A. | Ku |
| B. | P21 |
| C. | H2AX |
| D. | P53 |
| Answer» C. H2AX | |
| 2. |
Which of the following is not true about NHEJ? |
| A. | In most of the cases, it is associated with loss of genetic material |
| B. | Ku is present at a concentration as high as 400000 per cell |
| C. | It strand invasion looks for micro-homology regions |
| D. | The 3’overhang chewed up to chi sequence invades to search for homology |
| Answer» E. | |
| 3. |
Which of the following has both kinase and nuclease property? |
| A. | Pol Beta |
| B. | Ku-PKC |
| C. | Ku- pol gamma |
| D. | Pol delta |
| Answer» C. Ku- pol gamma | |
| 4. |
Which of the following is most flexible ligase? |
| A. | Ligase I |
| B. | ERCCI |
| C. | Ligase IV |
| D. | Ligase X |
| Answer» D. Ligase X | |
| 5. |
In DSB repair in G1 phase, which of these factors would be seen which is absent in other phases? |
| A. | RAD 51 |
| B. | MRN |
| C. | RAD 23 |
| D. | Ku 70/80 |
| Answer» E. | |
| 6. |
Which of the following is not true about ATM kinase? |
| A. | It is guided to the DSB site by MRN complex |
| B. | It exits as inactive dimer |
| C. | It is activated to monomer by another factor of DSB repair |
| D. | It phosphorylates BRCA1 and BRCA2 |
| Answer» D. It phosphorylates BRCA1 and BRCA2 | |
| 7. |
Which of these factors is not responsible for the assembly of Rec A oh the DNA? |
| A. | Rec B |
| B. | Rec F |
| C. | Rec R |
| D. | Rec O |
| Answer» C. Rec R | |
| 8. |
What is the structure of Rec A filament? |
| A. | Cylindrical |
| B. | Straight |
| C. | Like rolled beta sheet |
| D. | Alpha helical |
| Answer» E. | |
| 9. |
Which of these is not a part of the tri protein complex in homologous DSB repair? |
| A. | MRE11 |
| B. | NBS1 |
| C. | RAD 51 |
| D. | RAD 50 |
| Answer» D. RAD 50 | |
| 10. |
Which of the following will be a marker of DSB? |
| A. | H2A |
| B. | Gamma-P H2AX |
| C. | H5G |
| D. | Alpha-P H3BX |
| Answer» C. H5G | |
| 11. |
Rec BCD can chew 3’ end of the DSB till it reaches _____________ sequence. |
| A. | TATA |
| B. | Chi |
| C. | Phi |
| D. | Eta |
| Answer» C. Phi | |
| 12. |
What is the role of Rec BCD in DSB repair? |
| A. | It helps in strand invasion |
| B. | It chews off the flap |
| C. | It helps to generate 3’ overhang |
| D. | It helps by aligning the two homologous chromosomes |
| Answer» D. It helps by aligning the two homologous chromosomes | |
| 13. |
The DSB are indistinguishable from normal chromosomes of shorter length. |
| A. | True |
| B. | False |
| Answer» C. | |
| 14. |
Homologous recombination can’t occur in which stage? |
| A. | G2 |
| B. | Bacterial fission |
| C. | G1 |
| D. | S |
| Answer» D. S | |