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This section includes 697 Mcqs, each offering curated multiple-choice questions to sharpen your Biology knowledge and support exam preparation. Choose a topic below to get started.
51. |
Regarding the hypothalamus: |
A. | it has neural connections with the anterior pituitary gland |
B. | it integrates the vomiting reflex |
C. | the anterior hypothalamus responds to cold |
D. | it controls circadian rhythms via the supraoptic nuclei |
E. | it has osmoreceptors in the anterior hypothalamus to stimulate thirst and vasopressin release |
Answer» C. the anterior hypothalamus responds to cold | |
52. |
GABA: |
A. | decreases Cl- conductance |
B. | is broken down by glutamate decarboxylase (GA????) |
C. | there are five receptor subtypes |
D. | benzodiazepines bind to the subunit of the GABA receptor |
E. | is involved in 20% of CNS synapses |
Answer» F. | |
53. |
Regarding acetylcholine: |
A. | it is oxidised to choline and acetate by acetylcholinesterase |
B. | nicotinic receptors are blocked by atropine |
C. | it is the main excitatory transmitter in the spinal cord |
D. | it is secreted by the adrenal medulla |
E. | tetanus blocks its release at the NMJ |
Answer» F. | |
54. |
Regarding isometric ventricular reaction: |
A. | it occurs late in diastole |
B. | ventricular filling occurs |
C. | intraventricular pressure remains constant during this phase |
D. | it ends when the AV valve close |
E. | it ends when the AV valve open |
Answer» F. | |
55. |
Transmitters all are true EXCEPT: |
A. | angiotensin II is a neurotransmitter of the polypeptidillars |
B. | glutamate is an inhibitory amino acid |
C. | glucagons is found in hypothalamus and retina |
D. | vasopressin is found in posterior pituitary, medulla, spinal cord |
E. | serotonin is an amine |
Answer» C. glucagons is found in hypothalamus and retina | |
56. |
Local vasoconstriction results from: |
A. | increased potassium concentration |
B. | increased magnesium concentration |
C. | increased sodium concentration |
D. | decrease in pH |
E. | increased calcium concentration |
Answer» F. | |
57. |
Glomeruli: |
A. | minimally filters protein, so plasma protein concentration is not altered |
B. | are supplied by an extensive anastomotic arterial network |
C. | lie distal to the juxtaglomerular apparatus |
D. | each receive approximately 20-25% of resting cardiac output |
E. | do not filter appreciable albumin since membrane pores are too small |
Answer» D. each receive approximately 20-25% of resting cardiac output | |
58. |
Regarding sound and hearing: |
A. | high pitched sounds are detected at the apex of the cochlear |
B. | Harr cells are bathed in endolymph |
C. | defected by hair cells found within the tectorium membrane |
D. | 95% of afferent neurones outer ??? cells |
E. | supplied by retinal vessels |
Answer» F. | |
59. |
Lymph flow is: |
A. | an average 500ml/hr into the circulation |
B. | proportional to interstitial fluid pressure |
C. | increased with decreased interstitial fluid protein |
D. | decreased with contraction of muscles |
E. | decreased with elevated capillary pressure |
Answer» C. increased with decreased interstitial fluid protein | |
60. |
Regarding neurotrophins: |
A. | NGF and BDNF share the same receptor |
B. | the structure of the subunit of NGF resembles that of insulin |
C. | CNTF is necessary for the growth and maintenance of sympathetic neurons |
D. | disruption of GDNF by gene knockout causes a marked loss of cutaneous mechanoreceptors |
E. | none of the above are true |
Answer» C. CNTF is necessary for the growth and maintenance of sympathetic neurons | |
61. |
Hyperaldosteronism: |
A. | causes low plasmic Na+ and high H+ |
B. | retains acid H+ ions and can cause acidosis |
C. | doesn t cause oedema due to the escape phenomenon |
D. | may cause hypocalcaemic nephropathy |
E. | may be caused by high sodium intake |
Answer» D. may cause hypocalcaemic nephropathy | |
62. |
Ionic: |
A. | movement across an impermeable membrane occurs due to an osmotic gradient |
B. | equilibrium potential can be determined using the Nernst equation |
C. | movement across the capillary wall is not affected by the Donnan effect |
D. | valency determines osmotic effect in an ideal solution |
E. | forms of weak acids cross cell membranes easily |
Answer» C. movement across the capillary wall is not affected by the Donnan effect | |
63. |
More on muscles; which is TRUE? |
A. | skeletal muscle cells act as syncytram, though intercellular communications |
B. | some skeletal muscles are not subject to voluntary control |
C. | smooth muscle contains regularly discharging pacemaker |
D. | a variant of smooth muscle is found in the eye, which resembles skeletal muscle |
E. | cardiac muscle does not contain regular striation |
Answer» E. cardiac muscle does not contain regular striation | |
64. |
More on muscles; which is FALSE? |
A. | T tubules are extensions of extracellular space |
B. | cystems of SR are in contact with T-tubules |
C. | myosin molecules combine to form thick filaments while actin, tropomyosin, and the troponins the t .. |
D. | an individual muscle cell is a myofibril, containing myofilaments |
E. | the sarcolemnia transmits action potentials |
Answer» E. the sarcolemnia transmits action potentials | |
65. |
In regard to plasma volume: |
A. | it contributes to 10% of body weight |
B. | can easily be measured by radioisotope chromium |
C. | if the plasma volume is known, the blood volume can be calculated by multiplying100-HCT/100 |
D. | measured by injecting Evans blue |
E. | the average plasma volume is 500ml |
Answer» E. the average plasma volume is 500ml | |
66. |
Regarding HDL: |
A. | HDL transports ingested cholesterol from the intestine |
B. | HDL transports triglycerides from peripheral tissues |
C. | HDL receptors on macrophages are called scavenger receptors |
D. | elevated HDL levels are associated with increased risk of atherosclerosis |
E. | none of the above are correct |
Answer» D. elevated HDL levels are associated with increased risk of atherosclerosis | |
67. |
Regarding neurotransmitters, which of the following is INCORRECT? |
A. | glutamate is excitatory |
B. | GABA is inhibitory at presynaptic neurons |
C. | glycine is excitatory at postsynaptic neurons |
D. | GHB (gamma hydroxybutyrate) is inhibitory |
E. | aspartate is excitatory |
Answer» D. GHB (gamma hydroxybutyrate) is inhibitory | |
68. |
Neurotransmitters: |
A. | atropine blocks effect of acetylcholine at ???? receptor |
B. | reaction between active acetate and choline is catalysed by acetylcholinesterase |
C. | nicotinic cholinergic receptors are serpentine receptors |
D. | the rate limiting step in synthesis of NOVA is ?????(concussion) of tyrosine to dopa |
E. | MAOA is found in nerve endings and platelets |
Answer» E. MAOA is found in nerve endings and platelets | |
69. |
Regarding mitochondria, which of the following is TRUE? |
A. | 99% of mitochondrial proteins are products of mitochondrial DNA |
B. | the outer membrane of the mitochondria is folded to form cristae |
C. | the space between the outer and inner mitochondrial space is called matrix space |
D. | it is the sperm which contributes to the formation of mitochondria in the zygote |
E. | the synthesis of ATP in the mitochondria is triggered by diffusion of H+ from matrix to intracristal space |
Answer» F. | |
70. |
Ubiquitin is: |
A. | an essential amino acid |
B. | a polypeptide that tags proteins for degradation |
C. | a cell membrane glycoprotein |
D. | a precursor or uric acid |
E. | none of the above |
Answer» C. a cell membrane glycoprotein | |
71. |
Which of the following enzymes are missing in the zona glomerulosa? |
A. | 17 hydroxylase |
B. | 11 hydroxylase |
C. | 21 hydroxylase |
D. | cholesterol desmolase |
E. | 3 hydroxysteroid |
Answer» B. 11 hydroxylase | |
72. |
Creatinine: |
A. | is synthesised in the liver from methionine, glycine and anganine |
B. | is converted directly to creatine |
C. | has variable excretion from day to day |
D. | creatinuria occurs normally in the elderly and in pregnant women |
E. | all of the above |
Answer» E. all of the above | |
73. |
Regarding mitochondria: |
A. | genome inheritance is strictly maternal |
B. | the citric acid cycle occurs at the outer membrane |
C. | the space between the two membranes is called the matrix |
D. | the mutation rate for mitochondrial DNA is less than for nuclear DNA |
E. | involutions of the outer membrane are called cristae |
Answer» B. the citric acid cycle occurs at the outer membrane | |
74. |
What percentage of body weight is plasma? |
A. | 2% |
B. | 5% |
C. | 8% |
D. | 15% |
E. | 20% |
Answer» C. 8% | |
75. |
Regarding cellular components: |
A. | peroxisomes are larger than lysosomes |
B. | pH of lysosomes is higher than the rest of the cytoplasm |
C. | microfilaments are hollow |
D. | myosin 1 molecules are characteristically found in muscle cells |
E. | microfilaments are made up of actin |
Answer» F. | |
76. |
For neurotransmitters, which is TRUE? |
A. | acetylcholine is synthesised by true cholinesterase |
B. | atropine blocks muscarinic cholinergic receptors |
C. | catecholamines are formed from VMA (vanillylmandelic acid) |
D. | adrenaline has a higher affinity for rather than adrenergic receptors |
E. | dopamine is formed by COMT from tryptophan |
Answer» C. catecholamines are formed from VMA (vanillylmandelic acid) | |
77. |
For the genome, which is TRUE? |
A. | the human genome encodes 3 X 109 genes |
B. | adenine binds to cytosine and guanine to thymine |
C. | uracil replaces thymine in RNA |
D. | 3% of DNA are introns |
E. | haploid DNA in germ cells is single stranded |
Answer» D. 3% of DNA are introns | |
78. |
For mitochondria, which is TRUE? |
A. | NADH-DH, 5DH, bc, cox synthesise ATP |
B. | the matrix is between the inner and outer mitochondrial DNA |
C. | mitochondrial DNA is not transmitted paternally |
D. | 99% of mitochondrial proteins are encoded by mitochondrial DNA |
E. | ATP synthetase is powered by an electron gradient |
Answer» D. 99% of mitochondrial proteins are encoded by mitochondrial DNA | |
79. |
In muscle construction, which is TRUE? |
A. | only contraction is energy requiring, not relaxing |
B. | sequestering of Ca2+ causes separation of actin-myosin bands and muscle relaxation |
C. | ATPase clefts are on the tips of the myosin beads |
D. | ryanodine receptors are voltage gated Ca2+ chains |
E. | Troponin T inhibits the interaction of actin and myosin |
Answer» C. ATPase clefts are on the tips of the myosin beads | |
80. |
The golgi apparatus, which is TRUE? |
A. | is found only in secretory cells |
B. | vesicles containing newly synthesised proteins bind to trans side of the apparatus |
C. | constitutive pathway of cell secretion is responsible for further processing and storage of proteins |
D. | is responsible for glycorylation of proteins |
E. | none of the above |
Answer» F. | |
81. |
Bone: |
A. | osteoblasts are multinucleate |
B. | osteoclasts attach to bone via integins |
C. | compact bone makes up 60% of a long bone |
D. | osteoblasts secrete large quantities of type IV collagen and other bone matrix proteins |
E. | oestrogens inhibit osteoblasts and stimulate osteoclasts |
Answer» C. compact bone makes up 60% of a long bone | |
82. |
Which of the following is NOT a purine? |
A. | adenine |
B. | cytosine |
C. | guanine |
D. | hypoxanthine |
E. | xanthine |
Answer» C. guanine | |
83. |
Regarding plasma protein, all of the following are correct EXCEPT: |
A. | albumin, globulin and fibrinogen constitute the major plasma proteins in the plasma |
B. | the fibrinogen polymerises into long fibrin threads during blood coagulation |
C. | the principal function of albumin is to provide colloid osmotic pressure in the plasma |
D. | the majority of plasma proteins are formed in the lymphoid tissue |
E. | rapid loss of plasma proteins may occur during severe burns |
Answer» E. rapid loss of plasma proteins may occur during severe burns | |
84. |
Creatinine appears in the urine in significant amounts in all of the following EXCEPT: |
A. | normal men |
B. | thyrotoxicosis |
C. | post-partum |
D. | poorly controlled diabetes mellitus |
E. | children |
Answer» B. thyrotoxicosis | |
85. |
Regarding free fatty acids, which statement is INCORRECT? |
A. | circulate in plasma bound to globulin |
B. | they are the major source of energy for cardiac muscle |
C. | combine with glycerol to form the triglyceride of neutral fat |
D. | contain an even number of carbon atoms |
E. | require linkage to carnitine in order to cross mitochondrial membranes prior to oxidation |
Answer» B. they are the major source of energy for cardiac muscle | |
86. |
How many ATP molecules are produced from one glucose molecule metabolised aerobically via the Embden-Meyerhof pathway and citric acid cycle? |
A. | 32 |
B. | 34 |
C. | 36 |
D. | 38 |
E. | 40 |
Answer» E. 40 | |
87. |
Regarding cholesterol, which statement is INCORRECT? |
A. | dietary cholesterol is absorbed in the intestine and incorporated into chylomicrons formed in the mucosa |
B. | about 20% is in the plasma, with the remainder intracellular |
C. | negatively feeds back on its synthetic pathway |
D. | most hepatic synthesised cholesterol is incorporated into VLDL |
E. | thyroid hormones decrease the plasma cholesterol level |
Answer» C. negatively feeds back on its synthetic pathway | |
88. |
Which amino acid is NOT ketogenic (ie CAN T be converted into acetoacetate)? |
A. | leucine |
B. | isoleucine |
C. | phenylalanine |
D. | tyrosine |
E. | proline |
Answer» F. | |
89. |
Basal metabolic rate is GREATER in all of the following circumstances EXCEPT: |
A. | children compared with adults |
B. | Caucasians compared with Chinese and Indians |
C. | females compared with males |
D. | anxiety compared with depression |
E. | feeding compared with starvation |
Answer» D. anxiety compared with depression | |
90. |
Which lipoprotein contains the GREATEST proportion of triglyceride? |
A. | VLDL |
B. | IDL |
C. | chylomicrons |
D. | LDL |
E. | HDL |
Answer» D. LDL | |
91. |
Regarding endothelins, which statement is INCORRECT? |
A. | they can cause dose-dependent vasoconstriction in most vascular beds |
B. | they activate phospholipase C |
C. | they are structurally similar to vasoactive intestinal contractor |
D. | they have negative inotropic effect |
E. | there are low concentrations present in blood |
Answer» E. there are low concentrations present in blood | |
92. |
Which lipoprotein contains the GREATEST proportion of cholesterol and cholesterol esters? |
A. | VLDL |
B. | IDL |
C. | chylomicrons |
D. | LDL |
E. | HDL |
Answer» E. HDL | |
93. |
Regarding parathyroid hormone, which is NOT true? |
A. | it decreases plasma phosphate |
B. | it is secreted by chief cells of he parathyroid glands |
C. | it is cleared by Kupffer cells of the liver |
D. | its secretion is regulated by the level of bound Ca++ in plasma |
E. | it increases bone reabsorption |
Answer» E. it increases bone reabsorption | |
94. |
Which lipoprotein contains the GREATEST proportion of protein? |
A. | VLDL |
B. | IDL |
C. | chylomicrons |
D. | LDL |
E. | HDL |
Answer» F. | |
95. |
What is the basal metabolic rate of an average sized man per day? |
A. | 1000 Kcal |
B. | 2000 Kcal |
C. | 3000 Kcal |
D. | 4000 Kcal |
E. | 5000 Kcal |
Answer» C. 3000 Kcal | |
96. |
What is the most important factor affecting metabolic rate? |
A. | muscular exertion |
B. | recent ingestion of food |
C. | high or low environmental temperature |
D. | height, weight and surface area |
E. | sex |
Answer» B. recent ingestion of food | |
97. |
Which of the following are NON ESSENTIAL amino acids? |
A. | valine |
B. | leucine |
C. | isoleucine |
D. | cysteine |
E. | methionine |
Answer» E. methionine | |
98. |
Factors that predisposes to atherosclerosis includes all of the following EXCEPT: |
A. | diabetes |
B. | hypothyroidism |
C. | smoking |
D. | male sex |
E. | female sex hormone |
Answer» F. | |
99. |
Lipoproteins: |
A. | chylomicrons are themselves very large lipoproteins composed of cholesterol, phospholipids, triglycerides and proteins |
B. | VLDL contains a higher concentration of triglycerides and a moderate concentration of cholesterol and proteins |
C. | HDL contains a very higher concentration of cholesterol and a moderate concentration of phospholipids and triglycerides |
D. | the majority of the lipoproteins are synthesised in the liver |
E. | the primary function of the lipoproteins are to transport lipids in the blood from liver to adipose tissue |
Answer» D. the majority of the lipoproteins are synthesised in the liver | |
100. |
Regarding body surface area, which of the following statements is TRUE? |
A. | is calculated using weight/height |
B. | is calculated using 0.007184 X weight + 0.425 X weight + 0.725 |
C. | it does not affect the basal metabolic rate |
D. | it does not affect the general metabolic rate |
E. | it has an effect on the specific dynamic action of foodstuffs |
Answer» C. it does not affect the basal metabolic rate | |