MCQOPTIONS
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MCQOPTIONS
This section includes 44 Mcqs, each offering curated multiple-choice questions to sharpen your Immunology knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Match the antibioticsinGroup Iwith the targets in Group II.Group IP. Sulfonamide Q. Quinolones R. Erythromycin S. CephalosporinGroup II1. Peptidoglycan synthesis 2. Peptide chain elongation 3. Folic acid biosynthesis4. Topoisomerase |
| A. | P-3, Q-4, R-1, S-2 |
| B. | P-2, Q-4, R-3, S-1 |
| C. | P-4, Q-1, R-2, S-3 |
| D. | P-3, Q-4, R-2, S-1 |
| Answer» E. | |
| 2. |
Determine the correctness or otherwise of the following Assertion (A) and the Reason (R). Assertion : IgM is found in serum as a pentameric protein consisting of five IgM monomers. Reason : The pentameric form of IgM is due to cross-linking of IgM monomers via peptide bond. |
| A. | both (A) and (R) are true and (R) is the correct reason for (A) |
| B. | both (A) and (R) are true but (R) is not the correct reason for (A) |
| C. | (A) is true but (R) is false |
| D. | (A) is false but (R) is true |
| Answer» D. (A) is false but (R) is true | |
| 3. |
Match the items on the left column with those on the right LeftP. Programmed cell death at site of infection Q. Hormone upregulated during flooding stress R. Target for herbicide glyphosateS. Pathogen-derived resistance Right1. TMV coat protein2. EPSP synthase3. Hyper-sensitive response4. Ethylene |
| A. | P-l, Q-2, R-4, S-3 |
| B. | P-3, Q-4, R-2, S-l |
| C. | P-l, Q-4, R-2, S-3 |
| D. | P-3, Q-2, R-4, S-l |
| Answer» C. P-l, Q-4, R-2, S-3 | |
| 4. |
Determine the correctness or otherwise of the following Assertion[ a] and Reason [r] Assertion: An antigen recognized by one immunoglobulin subtype is not recognized by any other subtype. Reason: Immunoglobulin subtypes differ from each other body in the variable and in the constant regions. |
| A. | Both [a] and [r] are true and [r] is the correct reason for [a] |
| B. | Both [a] and [r] are true but [r] is not the correct reason for [a] |
| C. | Both [a] and [r] are false |
| D. | [a] is true but [r] is false |
| Answer» D. [a] is true but [r] is false | |
| 5. |
Match the activity spectrum of the following antibiotics P Actinomycin D1. AntifungalQ Daunorubicin2. AntituberculosisR Rifamycin3. AntitumorS Griseofulvin4. Antiprotosoal |
| A. | P-3 P-3 P-3 P-2 |
| B. | Q-4 Q-1 Q-1 Q-1 |
| C. | R-2 R-4 R-2 R-4 |
| D. | S-1 S-2 S-4 S-3 |
| Answer» B. Q-4 Q-1 Q-1 Q-1 | |
| 6. |
Match the recombinant products in group 1 with their therapeutic applications in group 2 Group 1P. Human growth hormoneQ. Platelet growth factorR. Factor VIII S. Erythropoietin Group 2 1. Pituitary dwarfism 2. Chemotherapy inducred thrombocy-topenia3. Haemophilia4. Anaemia associated with chronic renal failure |
| A. | P-l, Q-2, R-3, S-4 |
| B. | P-2, Q-1, R-3, S-4 |
| C. | P-l, Q-4, R-3, S-2 |
| D. | P-2, Q-4, R-3, S-l |
| Answer» B. P-2, Q-1, R-3, S-4 | |
| 7. |
In a mouse genome, the numbers of functional V , J , V , D , J gene segments are 79, 38, 21, 2 and 11, respectively. The total number of possible combinations for T cell receptors are ___ 106. |
| A. | 1.38 to 1.80 |
| B. | 2.78 to 3.90 |
| C. | 1.38 to 1.40 |
| D. | 0.08 to 1.80 |
| Answer» D. 0.08 to 1.80 | |
| 8. |
Which of the following statement(s) is/are CORRECT for antigen activated effector T cells?P. CD4+ cells make contact with macrophages and stimulate their microbicidal activity Q. CD4+ cells make contact with B cells and stimulate them to differentiate into plasma cells R. CD8+ cells make contact with B cells and stimulate them to differentiate into plasma cellsS. CD8+ cells make contact with virus infected cells and kill them |
| A. | Q only |
| B. | Q and S only |
| C. | P, Q and S only |
| D. | P, Q, R and S |
| Answer» D. P, Q, R and S | |
| 9. |
Match the antibiotics in Group I with their modes of action in Group II.Group IGroup IIP. Chloramphenicol1. Inhibits protein synth-esis by acting on 30S ribosomal subunitQ. Rifampicin2. Interferes with DNA replication by inhibiting DNA gyraseR. Tetracycline3. Inhibits protein synth-esis by acting on 50S ribosomal subunitS. Quinolone4. Interferes with RNA polymerase activity5. Inhibits -lactamase activity |
| A. | P-1, Q-2, R-3, S-5 |
| B. | P-3, Q-4, R-1, S-3 |
| C. | P-3, Q-2, R-1, S-4 |
| D. | P-1, Q-4, R-3, S-2 |
| Answer» C. P-3, Q-2, R-1, S-4 | |
| 10. |
Match the cells in Group I with their corresponding entries in Group II. Group IGroup IIP. Mast cells1. Activation of the comple-ment pathwayQ. Natural killer cells2. Expression of CD 56R. Neutrophils3. Containsazurophilic granulesS. Dendritic cells4. Defense against helminthic infection5. Production of antibodies specific to bacteria6. Contains long membranous projections |
| A. | P-4, Q-2, R-3, S-5 |
| B. | P-4, Q-2, R-3, S-6 |
| C. | P-3, Q-1, R-2, S-5 |
| D. | P-3, Q-1, R-2, S-6 |
| Answer» C. P-3, Q-1, R-2, S-5 | |
| 11. |
Detection of which hormone is the commonly used test for pregnancy in humans? |
| A. | LH |
| B. | FSH |
| C. | Charionic gonadotropin |
| D. | Estrogen |
| Answer» D. Estrogen | |
| 12. |
Antibody diversity is generated by |
| A. | Protein splicing |
| B. | Somatic mutation |
| C. | Allelic exclusion |
| D. | Inter-chromosomal recombination |
| Answer» D. Inter-chromosomal recombination | |
| 13. |
Find the INCORRECT combination. |
| A. | Surface immunoglobulins B cell antigen receptor |
| B. | Affinity maturation isotype switching |
| C. | Fc region of antibodies binding to complement proteins |
| D. | Spleen, the secondary lymphoid organ no connection with the lymphatic system |
| Answer» C. Fc region of antibodies binding to complement proteins | |
| 14. |
Which one of the following complement proteins is the initiator of the membrane attack complex ? |
| A. | C3a |
| B. | C3b |
| C. | C5a |
| D. | C5b |
| Answer» E. | |
| 15. |
Which of the following statement(s) is/are CORRECT for antigen activated effector T cells? |
| A. | Q only |
| B. | Q and S only |
| C. | P, Q and S only |
| D. | P, Q, R and S |
| Answer» D. P, Q, R and S | |
| 16. |
Based on the heavy chain, which one of the following antibodies has multiple subtypes ? |
| A. | IgM |
| B. | IgD |
| C. | IgE |
| D. | IgG |
| Answer» E. | |
| 17. |
The first humanized monoclonal antibody approved for the treatment of breast canceris |
| A. | Rituximab |
| B. | Cetuximab |
| C. | Bevacizumab |
| D. | Herceptin |
| Answer» E. | |
| 18. |
In ABO blood group system, antigenic determinants are |
| A. | nucleic acid |
| B. | carbohydrate |
| C. | lipid |
| D. | protein |
| Answer» C. lipid | |
| 19. |
Members of the antibody protein family that have common structural features are collectively known as |
| A. | haptens |
| B. | allergens |
| C. | antigens |
| D. | immunoglobulins |
| Answer» E. | |
| 20. |
Protein A, which has strong affinity to Fc region of immunoglobulin, is extracted from |
| A. | Saccharomyces cerevisiae |
| B. | Staphylococcus aureus |
| C. | Streptococcus pyogenes |
| D. | Streptococcus sanguis |
| Answer» C. Streptococcus pyogenes | |
| 21. |
In a mouse genome, the numbers of functional V |
| A. | 1.38 to 1.80 |
| B. | 2.78 to 3.90 |
| C. | 1.38 to 1.40 |
| D. | 0.08 to 1.80 |
| Answer» D. 0.08 to 1.80 | |
| 22. |
Match the antibioticsinGroup Iwith the targets in Group II. |
| A. | P-3, Q-4, R-1, S-2 |
| B. | P-2, Q-4, R-3, S-1 |
| C. | P-4, Q-1, R-2, S-3 |
| D. | P-3, Q-4, R-2, S-1 |
| Answer» E. | |
| 23. |
Which one of the following is an ABC transporter? |
| A. | multidrug resistance protein |
| B. | acetylcholine receptor |
| C. | bacteriorhodopsin |
| D. | ATP synthase |
| Answer» B. acetylcholine receptor | |
| 24. |
Endogenous antigens are presented on to the cell surface along with |
| A. | MHC-II |
| B. | MHC-I |
| C. | Fc receptor |
| D. | complement receptor |
| Answer» C. Fc receptor | |
| 25. |
Interferon- is produced by |
| A. | bacteria infected cells |
| B. | virus infected cells |
| C. | both virus and bacteria infected cells |
| D. | fungi infected cells |
| Answer» D. fungi infected cells | |
| 26. |
Hybridoma technology is used to produce |
| A. | monoclonal antibodies |
| B. | polyclonal antibodies |
| C. | both monoclonal and polyclonal antibodies |
| D. | B cells |
| Answer» B. polyclonal antibodies | |
| 27. |
Which of these mice fail to develop a thymus ? |
| A. | Motheaten mice |
| B. | Beige mice |
| C. | Knock out mice |
| D. | Nude mice |
| Answer» E. | |
| 28. |
Match the recombinant products in group 1 with their therapeutic applications in group 2 |
| A. | P-l, Q-2, R-3, S-4 |
| B. | P-2, Q-1, R-3, S-4 |
| C. | P-l, Q-4, R-3, S-2 |
| D. | P-2, Q-4, R-3, S-l |
| Answer» B. P-2, Q-1, R-3, S-4 | |
| 29. |
Dizygotic twins are connected to a single placenta during their embryonic development. These twins |
| A. | have identical MHC haplotypes |
| B. | have identical TH cells |
| C. | have identical T cells |
| D. | can accept grafts from each other (both (a) and (b) |
| Answer» E. | |
| 30. |
Match the activity spectrum of the following antibiotics |
| A. | P-3 P-3 P-3 P-2 |
| B. | Q-4 Q-1 Q-1 Q-1 |
| C. | R-2 R-4 R-2 R-4 |
| D. | S-1 S-2 S-4 S-3 |
| Answer» B. Q-4 Q-1 Q-1 Q-1 | |
| 31. |
Reverse vaccinology indicates |
| A. | From antigenic protein to vaccine development |
| B. | From antigenic polysaccharide to vaccine development |
| C. | From antibody to vaccine development |
| D. | From genome sequence to vaccine development |
| Answer» E. | |
| 32. |
Match the items on the left column with those on the right Left |
| A. | P-l, Q-2, R-4, S-3 |
| B. | P-3, Q-4, R-2, S-l |
| C. | P-l, Q-4, R-2, S-3 |
| D. | P-3, Q-2, R-4, S-l |
| Answer» C. P-l, Q-4, R-2, S-3 | |
| 33. |
Determine the correctness or otherwise of the following Assertion[ a] and Reason [r] |
| A. | Both [a] and [r] are true and [r] is the correct reason for [a] |
| B. | Both [a] and [r] are true but [r] is not the correct reason for [a] |
| C. | Both [a] and [r] are false |
| D. | [a] is true but [r] is false |
| Answer» D. [a] is true but [r] is false | |
| 34. |
Lymphocytes interact with foreign antigens in |
| A. | Bone marrow |
| B. | Peripheral blood |
| C. | Thymus |
| D. | Lymph nodes |
| Answer» E. | |
| 35. |
A neonatally thymectomized mouse, immunized with protein antigen shows |
| A. | both primary and secondary responses to the antigen |
| B. | only primary response to the antigen |
| C. | delayed type hypersensitive reactions |
| D. | no response to the antigen |
| Answer» C. delayed type hypersensitive reactions | |
| 36. |
Reactions between antibodies and antigens that are detected by precipitate formation in an agar gel are referred as |
| A. | immunoprecipitation assay |
| B. | immunodiffusion assay |
| C. | immunoaggregation assay |
| D. | immunofixation assay |
| Answer» C. immunoaggregation assay | |
| 37. |
Prior exposure of plants to pathogens is known to increase resistance to future pathogen attacks. This phenomenon is known as |
| A. | systemic acquired resistance |
| B. | hypersensitive response |
| C. | innate immunity |
| D. | antibody mediated response |
| Answer» B. hypersensitive response | |
| 38. |
Match the antibiotics in Group I with their modes of action in Group II. |
| A. | P-1, Q-2, R-3, S-5 |
| B. | P-3, Q-4, R-1, S-3 |
| C. | P-3, Q-2, R-1, S-4 |
| D. | P-1, Q-4, R-3, S-2 |
| Answer» C. P-3, Q-2, R-1, S-4 | |
| 39. |
Which of the following statements is most appropriate for recombinant antibody production in transgenic plants? |
| A. | A very high level expression is always obtained |
| B. | Light promote more antibody production |
| C. | Such antibodies are free from other antigen of animal origin |
| D. | Functional antibody cannot be produced in plants |
| Answer» D. Functional antibody cannot be produced in plants | |
| 40. |
Match the cells in Group I with their corresponding entries in Group II. |
| A. | P-4, Q-2, R-3, S-5 |
| B. | P-4, Q-2, R-3, S-6 |
| C. | P-3, Q-1, R-2, S-5 |
| D. | P-3, Q-1, R-2, S-6 |
| Answer» C. P-3, Q-1, R-2, S-5 | |
| 41. |
Production of monoclonal antibodies by hybridoma technology requires |
| A. | splenocytes |
| B. | osteocytes |
| C. | hepatocytes |
| D. | thymocytes |
| Answer» B. osteocytes | |
| 42. |
Recombinant live attenuated vaccine against hepatitis B was prepared from |
| A. | Plasma of chronically infected individual |
| B. | Recombinant yeast expressing hepatitis B surface antigen |
| C. | Recombinant vaccinia virus expressing hepatitis B surface antigen |
| D. | Transgenic plants expressing hepatitis B surface antigen |
| Answer» D. Transgenic plants expressing hepatitis B surface antigen | |
| 43. |
Viral replication within cells is inhibited by |
| A. | IL 4 |
| B. | IL 1 |
| C. | IFN |
| D. | TNF |
| Answer» D. TNF | |
| 44. |
The role of an adjuvant is to |
| A. | prolong the persistence of antigen |
| B. | cross link the antigen |
| C. | increase the size of antigen |
| D. | avoid inflammation |
| Answer» B. cross link the antigen | |