MCQOPTIONS
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MCQOPTIONS
This section includes 61 Mcqs, each offering curated multiple-choice questions to sharpen your Antibody knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the immunoglobulin isotype have the longest half-life? |
| A. | IgG |
| B. | IgM |
| C. | IgA |
| D. | IgE |
| Answer» B. IgM | |
| 2. |
Which of the following subclass of IgG does not readily cross the placental barriers? |
| A. | IgG1 |
| B. | IgG2 |
| C. | IgG3 |
| D. | IgG4 |
| Answer» C. IgG3 | |
| 3. |
Which of the immunoglobulin isotype have the shortest half-life? |
| A. | IgG |
| B. | IgM |
| C. | IgA |
| D. | IgE |
| Answer» E. | |
| 4. |
Which of the following subclass of IgG molecule is the most potent activator of complement pathway? |
| A. | IgG1 |
| B. | IgG2 |
| C. | IgG3 |
| D. | IgG4 |
| Answer» D. IgG4 | |
| 5. |
Which of the following complement is bound by IgG? |
| A. | C2a |
| B. | C2b |
| C. | C3a |
| D. | C3b |
| Answer» E. | |
| 6. |
B-cell receptor consist of membrane-bound immunoglobulin and a small heterodimer protein required for signaling. Which of the following is the heterodimer protein? |
| A. | Ig & Ig |
| B. | Ig & Ig |
| C. | Ig & Ig |
| D. | None of Above |
| Answer» B. Ig & Ig | |
| 7. |
Multiple Myeloma is characterized by excessive production of immunoglobulin and presence of light chain in urine. Which of the following cells are responsible for the production of immunoglobulin |
| A. | T cells |
| B. | B-cells |
| C. | Plasma cells |
| D. | Dendritic cells |
| Answer» D. Dendritic cells | |
| 8. |
The immunoglobulin superfamily is the group of membrane proteins that possess one or more homologous immunoglobulin domain. Which of the following is NOT immunoglobulin superfamily? |
| A. | T cell receptor |
| B. | beta2 microglobulin |
| C. | Insulin receptor |
| D. | Platelet-derived growth factor |
| Answer» D. Platelet-derived growth factor | |
| 9. |
The Fc receptor is a plasma membrane glycoprotein that binds to different immunoglobulin and triggers effective functions. Which of the following Fc receptor is involved in the transfer of IgG from mother to fetus |
| A. | Fc R |
| B. | FcRN |
| C. | Fc R |
| D. | Fc R |
| Answer» C. Fc R | |
| 10. |
Which of the following antigen-bound antibodies bind to the Fc receptor present on the basophils and tissue mast cells, and releases various pharmacoactive mediators involved in anaphylaxis? |
| A. | IgA |
| B. | IgD |
| C. | IgE |
| D. | IgM |
| Answer» D. IgM | |
| 11. |
The hinge region of the immunoglobulin consists of the disulfide bond that held the heterotetramer together. Also, it contributes to the flexibility of the antibody chain. Which of the following antibody class do not have a hinge region? |
| A. | IgA |
| B. | IgD |
| C. | IgE |
| D. | IgG |
| Answer» D. IgG | |
| 12. |
The hypervariable complementarity determining region is responsible for which of the following function |
| A. | binding to antigen |
| B. | binding to FcR |
| C. | binding to complement |
| D. | None of the above |
| Answer» B. binding to FcR | |
| 13. |
The monomeric immunoglobulin consists of heterodimers of heavy (H) and light (L) chain bound together by non-covalent interaction and disulfide bonds. Which of the following is the antigen binding site? |
| A. | Fab |
| B. | Fc |
| C. | Hinge region |
| D. | None of the above |
| Answer» B. Fc | |
| 14. |
Globulins of the blood plasma are responsible for |
| A. | defence mechanisms |
| B. | blood clotting |
| C. | oxygen transport |
| D. | osmotic balance |
| Answer» B. blood clotting | |
| 15. |
Interferons are |
| A. | antibiotic proteins |
| B. | antiviral proteins |
| C. | antigen proteins |
| D. | all of the above |
| Answer» C. antigen proteins | |
| 16. |
Antibodies are |
| A. | prostaglandins |
| B. | steroids |
| C. | lipoproteins |
| D. | glycoproteins |
| Answer» E. | |
| 17. |
The IgA and IgMs consist of the following chain that allows its polymerization. |
| A. | H chain |
| B. | L chain |
| C. | J chain |
| D. | V chain |
| Answer» D. V chain | |
| 18. |
Which of the following class of immunoglobulin is dimeric structure? |
| A. | IgA |
| B. | IgD |
| C. | IgH |
| D. | IgM |
| Answer» B. IgD | |
| 19. |
Which of the following class of immunoglobulin is pentameric structure? |
| A. | IgA |
| B. | IgD |
| C. | IgH |
| D. | IgM |
| Answer» E. | |
| 20. |
The five classes of immunoglobulin include the following except |
| A. | IgA |
| B. | IgD |
| C. | IgE |
| D. | IgH |
| Answer» E. | |
| 21. |
Mabs are produced by |
| A. | in vivo method |
| B. | suspended cell culture in fermenters |
| C. | Immobilized cell reactors |
| D. | all of these |
| Answer» E. | |
| 22. |
The major hazards of Mabs are |
| A. | difficult in purification |
| B. | contamination with retroviral particles from mouse myeloma cells |
| C. | non specificity |
| D. | all of these |
| Answer» C. non specificity | |
| 23. |
Mabs are used in |
| A. | the screening of recombinants |
| B. | diagnostic kits |
| C. | the treatment of many cancers |
| D. | all of these |
| Answer» E. | |
| 24. |
Which of the following immunoglobulins makes the largest percentage in breast milk? |
| A. | IgM |
| B. | IgD |
| C. | IgG |
| D. | IgA |
| Answer» E. | |
| 25. |
Transplanted graft may be rejected due to |
| A. | cell-mediated immune response |
| B. | humoral immune response |
| C. | innate immune response |
| D. | passive response |
| Answer» B. humoral immune response | |
| 26. |
Oral polio drops contain |
| A. | harvested antibodies |
| B. | activated pathogens |
| C. | attenuated pathogens |
| D. | gamma globulins |
| Answer» D. gamma globulins | |
| 27. |
The order of percent of total immunoglobulin in serum is, |
| A. | IgM, IgA, IgG, IgD, IgE |
| B. | IgG, IgA, IgM, IgE, IgD |
| C. | IgG, IgA, IgM, IgE, IgD |
| D. | IgG, IgA, IgM, IgD, IgE |
| Answer» E. | |
| 28. |
Which of the following antibody is prominent antigen receptor expressed on B Cells? |
| A. | IgG |
| B. | IgA |
| C. | IgM |
| D. | IgE |
| Answer» D. IgE | |
| 29. |
Which of the following immunoglobulin has the highest avidity of the immunoglobulins? |
| A. | IgA |
| B. | IgM |
| C. | IgE |
| D. | IgG |
| Answer» C. IgE | |
| 30. |
Which of the following immunoglobulin is the main host defense against parasititc infections? |
| A. | Secretory IgA |
| B. | IgG |
| C. | IgM |
| D. | IgE |
| Answer» E. | |
| 31. |
Which of the following immunoglobulin is the most abundant immunoglobulin in newborns? |
| A. | IgA |
| B. | IgM |
| C. | IgG |
| D. | IgD |
| Answer» D. IgD | |
| 32. |
Whch of the following immunoglobulin is produced early in the primary response to infection? |
| A. | IgE |
| B. | IgA |
| C. | IgG |
| D. | IgM |
| Answer» E. | |
| 33. |
Which of the following antibodies is predominantly present in tears, saliva and mucous |
| A. | IgM |
| B. | IgG |
| C. | IgE |
| D. | IgA |
| Answer» E. | |
| 34. |
Which of the following antibody is an important host defense against encapsulated bacteria? |
| A. | IgG1 |
| B. | IgG2 |
| C. | IgG3 |
| D. | IgG4 |
| Answer» C. IgG3 | |
| 35. |
The class of antibodies, which can cross placenta is |
| A. | IgD |
| B. | IgA |
| C. | IgG |
| D. | IGM |
| Answer» D. IGM | |
| 36. |
Type I hypersensitivity involves |
| A. | IgD |
| B. | IgM |
| C. | IgE |
| D. | IgG |
| Answer» D. IgG | |
| 37. |
Which of the following antibody directly take part in opsonization process? |
| A. | IgM |
| B. | IgG |
| C. | IgA |
| D. | IgE |
| Answer» C. IgA | |
| 38. |
Complement fixation is one of the most important host defense against infections. The complement is activated by; |
| A. | IgM Only |
| B. | IgG only |
| C. | both IgM and IgG |
| D. | all five classes of antibodies activate complements. |
| Answer» D. all five classes of antibodies activate complements. | |
| 39. |
The antibody which is found in secretions is: |
| A. | IgD |
| B. | IgE |
| C. | IgG |
| D. | IgA |
| Answer» E. | |
| 40. |
Natural humoral immune response against a pathogen leads to the production of |
| A. | polyclonal antibodies |
| B. | monoclonal antibodies |
| C. | macrophages |
| D. | none of these |
| Answer» B. monoclonal antibodies | |
| 41. |
Monoclonal antibodies are |
| A. | heterogenous antibodies produced from single clone of plasma cells |
| B. | homogenous antibodies produced from single clone of plasma cells |
| C. | both a and b |
| D. | none of these |
| Answer» C. both a and b | |
| 42. |
Which of the following statement is incorrect regarding HAT selection |
| A. | B cells are HGPRT + and can grow in HAT medium but undergoes normal cell death |
| B. | Myeloma cells cannot grow in HAT medium as these cells lack HGPRT |
| C. | Hybrid cell survive in HAT medium as it inherits HGPRT form B cells |
| D. | Aminopterin in HAT medium blocks de novo pathway of nucleotide synthesis only in myeloma cells |
| Answer» E. | |
| 43. |
In hybridoma technology, hybrid cells are selected in |
| A. | MS medium |
| B. | HAT medium |
| C. | x-gal medium |
| D. | Whites medium |
| Answer» C. x-gal medium | |
| 44. |
Which of the following cell is made deficient of hypoxanthine guanyl phosphoribosyl transferase (HGPRT) enzyme |
| A. | B cells |
| B. | hybrid cells |
| C. | myeloma cells |
| D. | none of these |
| Answer» D. none of these | |
| 45. |
HGPRT- mutant cells are raised by inducing mutations using |
| A. | 5-bromouracil |
| B. | 8-azaguanine |
| C. | colchicine |
| D. | 6-methy isocyanate |
| Answer» C. colchicine | |
| 46. |
Which of the following statement is incorrect regarding HAT medium |
| A. | HAT medium is a selective medium |
| B. | Aminiopterin in the HAT medium blocks de novo pathway of nucleotide synthesis |
| C. | Salvage pathway requires aminopterin and thymidine |
| D. | Hypoxanthin is converted to guanine by HGPRT enzyme |
| Answer» D. Hypoxanthin is converted to guanine by HGPRT enzyme | |
| 47. |
Mabs are |
| A. | specific towards a paratope |
| B. | specific towards an epitope |
| C. | specific towards an antigen |
| D. | none of these |
| Answer» C. specific towards an antigen | |
| 48. |
The hybridomas are made by |
| A. | fusing T cells with myeloma cells |
| B. | fusing B cells with myeloma cells |
| C. | fusing T helper cells with myeloma cells |
| D. | fusing B memory cells with myeloma cells |
| Answer» C. fusing T helper cells with myeloma cells | |
| 49. |
All are Mabs except |
| A. | Rituximab |
| B. | Transtuzumab |
| C. | Infliximab |
| D. | tamoxifen |
| Answer» E. | |
| 50. |
Hybridoma technology was developed by |
| A. | Kohler and Milstein |
| B. | Khorana and Nirenberg |
| C. | Khorana and Korenberg |
| D. | Beedle and Tautum |
| Answer» B. Khorana and Nirenberg | |