MCQOPTIONS
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MCQOPTIONS
This section includes 20 Mcqs, each offering curated multiple-choice questions to sharpen your Cytogenetics knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
For very large number of repeats in Huntington’s disease, the phenotype can appear at 20 years of age. |
| A. | True |
| B. | False |
| Answer» B. False | |
| 2. |
What is the threshold number of repeats in Huntington’s disease? |
| A. | 15 |
| B. | 27 |
| C. | 36 |
| D. | 42 |
| Answer» D. 42 | |
| 3. |
Huntington’s disease is due to the __________ trinucleotide repeats. |
| A. | CGG |
| B. | CTG |
| C. | CAG |
| D. | CGA |
| Answer» D. CGA | |
| 4. |
Only sons of the daughter whose father was NTM will be affected by the disease- fragile X chromosome. |
| A. | True |
| B. | False |
| Answer» C. | |
| 5. |
Fragile X chromosome affects the __________ gene. |
| A. | H19 |
| B. | Igf2 |
| C. | SEC |
| D. | FMR1 |
| Answer» E. | |
| 6. |
FRAGILE_X_CHROMOSOME_AFFECTS_THE____________GENE.?$ |
| A. | H19 |
| B. | Igf2 |
| C. | SEC |
| D. | FMR1 |
| Answer» E. | |
| 7. |
Huntington’s disease is due to the __________ trinucleotide repeats.$# |
| A. | CGG |
| B. | CTG |
| C. | CAG |
| D. | CGA |
| Answer» D. CGA | |
| 8. |
Only sons of the daughter whose father was NTM will be affected by the disease- fragile X chromosome.$ |
| A. | True |
| B. | False |
| Answer» C. | |
| 9. |
Phenyl ketone urea is expected to increase __________ by the next 30 years due to the Dysgenic effect of medicine? |
| A. | 10% |
| B. | 30% |
| C. | 100% |
| D. | 300% |
| Answer» E. | |
| 10. |
Dysgenic effect of medicine is ______________ |
| A. | Disobeying Mendalian principle |
| B. | Against Darwin’s theory |
| C. | Leads to strengthening of the society |
| D. | Diseases become scarce |
| Answer» C. Leads to strengthening of the society | |
| 11. |
For very large number of repeats in Huntington’s disease, the phenotype can appear at 20 years of age.$ |
| A. | True |
| B. | False |
| Answer» B. False | |
| 12. |
What is the threshold number of repeats in Huntington’s disease?$ |
| A. | 15 |
| B. | 27 |
| C. | 36 |
| D. | 42 |
| Answer» D. 42 | |
| 13. |
Which of the following can explain anticipation? |
| A. | Due to slippage of the trinucleotide repeats we will see gradually all the repeat number increases as does the defective phenotype |
| B. | The child always expresses the phenotype more severely than unaffected parent |
| C. | The number of repeat beyond a particular threshold leads to improper replication |
| D. | It is inherited like linkage |
| Answer» D. It is inherited like linkage | |
| 14. |
Foe fragile X chromosome which of the following is wrong? |
| A. | The father having 50 nt repeats or above leads to disease in daughter |
| B. | Daughter has 50-200 repeats |
| C. | The grandson has 200-1300 repeats |
| D. | The grandson shows the disease phenotype |
| Answer» B. Daughter has 50-200 repeats | |
| 15. |
Which of the following individuals will have fragile X chromosome? |
| A. | 6 repeats of CGG |
| B. | 50 repeats of CGG |
| C. | 150 repeats of CGG |
| D. | 700 repeats of CGG |
| Answer» E. | |
| 16. |
Fragile X chromosome is due to the ____________ repeats? |
| A. | CGG |
| B. | CAG |
| C. | GGC |
| D. | CAA |
| Answer» B. CAG | |
| 17. |
Anticipation is not seen in which of the following? |
| A. | Fragile X chromosome |
| B. | Duchenne muscular dystrophy |
| C. | Myotonic dystrophy |
| D. | Huntingtons’s disease |
| Answer» C. Myotonic dystrophy | |
| 18. |
Dynamic mutation is mainly due to _____________ nucleotide repeats. |
| A. | Single |
| B. | Two |
| C. | Three |
| D. | four |
| Answer» D. four | |
| 19. |
Dynamic mutation depends on which of the following? |
| A. | Presence of a gene |
| B. | The number of repeats |
| C. | The location of the gene |
| D. | The methylation state of the gene |
| Answer» C. The location of the gene | |
| 20. |
Dynamic mutation is _________________ |
| A. | Heritable |
| B. | Non-heritable |
| C. | Epigenetic |
| D. | Environmental |
| Answer» B. Non-heritable | |