 
			 
			MCQOPTIONS
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				This section includes 20 Mcqs, each offering curated multiple-choice questions to sharpen your Biochemistry knowledge and support exam preparation. Choose a topic below to get started.
| 1. | Which type of supercoiling takes the form of extended right-handed coils? | 
| A. | Plectonemic supercoiling | 
| B. | Solenoidal supercoiling | 
| C. | Negative supercoiling | 
| D. | Positive supercoiling | 
| Answer» B. Solenoidal supercoiling | |
| 2. | Under-winding is measured in terms of ____________ | 
| A. | Supercoiling | 
| B. | Linking difference | 
| C. | Positive supercoiling | 
| D. | Negative supercoiling | 
| Answer» C. Positive supercoiling | |
| 3. | The type I enzyme(s) is/are ____________ | 
| A. | Topoisomerases I and III | 
| B. | Topoisomerases II | 
| C. | Topoisomerase IV | 
| D. | Topoisomerases I and IV | 
| Answer» B. Topoisomerases II | |
| 4. | The type of topoisomerases that can introduce negative supercoils is ____________ | 
| A. | Type I | 
| B. | Type II | 
| C. | Type III | 
| D. | Type IV | 
| Answer» C. Type III | |
| 5. | The type of topoisomerases which generally relaxes DNA by removing negative supercoiling? | 
| A. | Type I | 
| B. | Type II | 
| C. | Type III | 
| D. | Type IV | 
| Answer» B. Type II | |
| 6. | The enzyme responsible for the removal of supercoiling in replicating DNA ahead of the replication fork is ____________ | 
| A. | Topoisomerase | 
| B. | Primase | 
| C. | DNA polymerase | 
| D. | Helicase | 
| Answer» B. Primase | |
| 7. | Changing twist from the relaxed state requires adding energy and increases the ____________ | 
| A. | Forces in molecule | 
| B. | Stress along molecule | 
| C. | Strain over molecule | 
| D. | None of the above | 
| Answer» C. Strain over molecule | |
| 8. | Over-twisting of a molecule results in ____________ | 
| A. | Negative supercoiling | 
| B. | Positive supercoiling | 
| C. | Elongation | 
| D. | Compression | 
| Answer» C. Elongation | |
| 9. | When there is no net bending of the DNA axis upon itself, the DNA is said to be in a ____________ | 
| A. | Elongated state | 
| B. | Compressed state | 
| C. | Relaxed state | 
| D. | Denatured state | 
| Answer» D. Denatured state | |
| 10. | The phenomenon of twisting around itself by a molecule to relieve helical stress is ____________ | 
| A. | Supercoiling | 
| B. | Coiling | 
| C. | Elongation | 
| D. | Compression | 
| Answer» B. Coiling | |
| 11. | UNDER-WINDING_IS_MEASURED_IN_TERMS_OF?$ | 
| A. | Supercoiling | 
| B. | Linking difference | 
| C. | Positive supercoiling | 
| D. | Negative supercoiling | 
| Answer» C. Positive supercoiling | |
| 12. | Which type of supercoiling takes the form of extended right-handed coils?$ | 
| A. | Plectonemic supercoiling | 
| B. | Solenoidal supercoiling | 
| C. | Negative supercoiling | 
| D. | Positive supercoiling | 
| Answer» B. Solenoidal supercoiling | |
| 13. | The type I enzyme(s) is/ar? | 
| A. | Topoisomerases I and III | 
| B. | Topoisomerases II | 
| C. | Topoisomerase IV | 
| D. | Topoisomerases I and IV | 
| Answer» B. Topoisomerases II | |
| 14. | The type of topoisomerases that can introduce negative supercoils is | 
| A. | Type I | 
| B. | Type II | 
| C. | Type III | 
| D. | Type IV | 
| Answer» C. Type III | |
| 15. | The type of topoisomerases which generally relaxes DNA by removing negative supercoiling is | 
| A. | Type I | 
| B. | Type II | 
| C. | Type III | 
| D. | Type IV | 
| Answer» B. Type II | |
| 16. | The enzyme responsible for the removal of supercoiling in replicating DNA ahead of the replication fork is | 
| A. | Topoisomerase | 
| B. | Primase | 
| C. | DNA polymerase | 
| D. | Helicase | 
| Answer» B. Primase | |
| 17. | Changing twist from relaxed state requires adding energy and increases the | 
| A. | Forces in molecule | 
| B. | Stress along molecule | 
| C. | Strain over molecule | 
| D. | None of the above | 
| Answer» C. Strain over molecule | |
| 18. | Over-twisting of a molecule results in | 
| A. | Negative supercoiling | 
| B. | Positive supercoiling | 
| C. | Elongation | 
| D. | Compression | 
| Answer» C. Elongation | |
| 19. | When there is no net bending of the DNA axis upon itself, the DNA is said to be in a | 
| A. | Elongated state | 
| B. | Compressed state | 
| C. | Relaxed state | 
| D. | Denatured state | 
| Answer» D. Denatured state | |
| 20. | The phenomenon of twisting around itself by a molecule to relieve helical stress is | 
| A. | Supercoiling | 
| B. | Coiling | 
| C. | Elongation | 
| D. | Compression | 
| Answer» B. Coiling | |