MCQOPTIONS
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MCQOPTIONS
This section includes 14 Mcqs, each offering curated multiple-choice questions to sharpen your Protein Engineering knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the following ion co-ordinates the oligomerization of three insulin dimers to form a hexamer? |
| A. | Sodium ions |
| B. | Calcium ions |
| C. | Copper ions |
| D. | Zinc ions |
| Answer» E. | |
| 2. |
Which of the following amino acid when inserted in the insulin chain significantly reduces the monomeric interactions? |
| A. | Methionine |
| B. | Valine |
| C. | Glycine |
| D. | Glutamic acid |
| Answer» E. | |
| 3. |
In Engineered slow-acting insulin (Lantus) the asparagine residue 21 of the A chain is replaced by glycine, and this chain is elongated at its C-terminal end by two arginine residues. |
| A. | True |
| B. | False |
| Answer» C. | |
| 4. |
The introduction of amino acid substitutions that will discourage the monomer interaction is to be done inside the insulin receptor binding site. |
| A. | True |
| B. | False |
| Answer» C. | |
| 5. |
Which of the following is the trade name of engineered slow-acting insulin? |
| A. | Novorapid |
| B. | Novolog |
| C. | Novolin |
| D. | Lantus |
| Answer» E. | |
| 6. |
Find the odd one out with respect to engineered fast-acting insulins. |
| A. | Arginine |
| B. | Aspartic acid |
| C. | Histidine |
| D. | Valine |
| Answer» E. | |
| 7. |
Engineered slow-acting insulin is not fully soluble at which of the following pH? |
| A. | pH 5.5 |
| B. | pH 5 |
| C. | pH 4 |
| D. | pH 7 |
| Answer» E. | |
| 8. |
Which of the following amino acid cannot be inserted to minimize the monomer interactions? |
| A. | Glutamate |
| B. | Arginine |
| C. | Lysine |
| D. | Proline |
| Answer» E. | |
| 9. |
Which of the following cells are destroyed in type 1 diabetes? |
| A. | Immune cells |
| B. | Gamma cell |
| C. | Alpha cells |
| D. | Beta cells |
| Answer» E. | |
| 10. |
A combination of fast-acting and slow-acting insulin must usually be administered to diabetics to mimic the natural state. |
| A. | False |
| B. | True |
| Answer» C. | |
| 11. |
At physiological concentrations (10-10 M), insulin molecules exist in oligomeric form. |
| A. | True |
| B. | False |
| Answer» C. | |
| 12. |
Which of the following consists of a 21 amino acid A-chain linked to a 30 amino acid B chain via two interchain disulfide linkages? |
| A. | Somatostatin |
| B. | Glucagon |
| C. | Hemoglobin |
| D. | Insulin |
| Answer» E. | |
| 13. |
Which of the following is not true for a healthy person? |
| A. | The pancreas secretes insulin continuously |
| B. | Transient increase in insulin secretion |
| C. | Beta cells secrete insulin |
| D. | Insulin is only secreted after a meal |
| Answer» E. | |
| 14. |
Which of the following is the main reason for type 2 diabetes? |
| A. | Insulin overproduction |
| B. | Insulin deficiency |
| C. | Insulin destruction |
| D. | Insulin resistance |
| Answer» E. | |