MCQOPTIONS
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MCQOPTIONS
This section includes 15 Mcqs, each offering curated multiple-choice questions to sharpen your Protein Engineering knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Which of the following was constructed to further minimize the mouse component of antibodies? |
| A. | Murine antibodies |
| B. | Anti-chimeric antibodies |
| C. | Chimeric antibodies |
| D. | Humanized antibodies |
| Answer» E. | |
| 2. |
Which of the following would allow lower doses of antibodies to elicit a more profound biological activity? |
| A. | Improvement of the primary structure of a protein |
| B. | Improvement of antigen dissociation affinity |
| C. | Elimination of glycosylation of protein |
| D. | Improvement of antigen-binding affinity |
| Answer» E. | |
| 3. |
Which of the following is a method to increase the half-lives of antibody fragments? |
| A. | Improvement of CDC |
| B. | Acetylation |
| C. | Fragment annealing |
| D. | PEGylation |
| Answer» E. | |
| 4. |
Chimeric antibodies do not induce an immunogenic response in humans. |
| A. | True |
| B. | False |
| Answer» C. | |
| 5. |
Which of the following immunoglobulin can be suitable for diagnostic imaging or blocking molecular interactions? |
| A. | IgG3 |
| B. | IgG2 |
| C. | IgG1 |
| D. | IgG4 |
| Answer» E. | |
| 6. |
CDC is dependent upon binding of which of the following to the hinge and CH2 domain of antibodies? |
| A. | One molecule of C1q |
| B. | Two molecules of C1rs |
| C. | One molecule of C1r |
| D. | Two molecules of C1qs |
| Answer» E. | |
| 7. |
Therapeutic antibodies can work by blocking ligand-receptor interaction or by triggering an intracellular signal, such as apoptosis. |
| A. | False |
| B. | True |
| Answer» C. | |
| 8. |
Which of the following was constructed to reduce the immunogenicity of murine antibodies in humans? |
| A. | Monoclonal antibodies |
| B. | Anti-murine antibodies |
| C. | Anti-chimeric antibodies |
| D. | Chimeric antibodies |
| Answer» E. | |
| 9. |
Which of the following region is associated with serum half-life? |
| A. | Hinge region |
| B. | Fab region |
| C. | Fc and Fab region |
| D. | Fc region |
| Answer» E. | |
| 10. |
Which of the following feature is not taken into consideration when an antibody is designed as a drug? |
| A. | Immunogenicity |
| B. | Affinity |
| C. | Stability |
| D. | Primary structure |
| Answer» E. | |
| 11. |
Which of the following is most suitable for the therapeutic use against pathogens or tumor cells? |
| A. | IgG3 |
| B. | IgG4 |
| C. | IgG2 |
| D. | IgG1 |
| Answer» E. | |
| 12. |
A single-chain variable fragment (ScFv) consists of which of the following? |
| A. | VH & CH |
| B. | VL only |
| C. | VH only |
| D. | VH & VL |
| Answer» E. | |
| 13. |
The hypervariable loops are primarily responsible for antigen recognition and referred to as complementarity determining regions. |
| A. | False |
| B. | True |
| Answer» C. | |
| 14. |
Which of the following is not a class of immunoglobulins? |
| A. | IgA |
| B. | IgD |
| C. | IgE |
| D. | IgB |
| Answer» E. | |
| 15. |
Which of the following feature makes antibodies attractive drug candidates? |
| A. | It being a glycoprotein |
| B. | Low target specificity |
| C. | Catalytic efficiency |
| D. | High target specificity |
| Answer» E. | |