Microtubules and microfilaments are two components in the cytoskeleton. The main difference between microtubules and microfilaments is in their structure and function. Microtubules have a long, hollow cylindrical structure. They are formed by the polymerization of tubulin proteins. The major role of microtubules is to provide mechanical support to the cell, involve in chromosomal segregation and maintain the transport of components inside the cell. On the other hand, microfilaments are helical structures, more strong and flexible compared to microtubules. They are involved in the movement of the cell on a surface. Both microtubules and microfilaments are dynamic structures. Their dynamic nature is regulated by associated proteins with the polymers.