Which of the following statements is true about uncompetitive inhibitors?

• A. They bind covalently at a site distinct from the substrate active site
• B. In the presence of a uncompetitive inhibitor, the Michaelis-Menten equation becomes\(V_0 = \frac{V_{max} [S]}{K_m+α’ [S]} \)
• C. They increase the measured Vmax⁡
• D. Apparent Km also increases