Which is true of thrombolysis in cerebral infarct?

• A. Clear benefit has been shown in at least 2 randomized controlled trials that TPA reduces mortality in CVA.
• B. Patients up to 6 hrs post infarct have been shown to benefit from thrombolysis.
• C. Larger infarcts tend to have more benefit from thrombolysis.
• D. The NINDS trial showed that improvement in patients treated within 3 hrs with thrombolysis.
• E. ECASS trial thrombolysed patients within 3 hrs with TPA and showed improvements in all outcomes compared with placebo.