The concept of induced fit refers to the fact that _______

• A. When a substrate binds to an enzyme, the enzyme induces a loss of water (desolvation) from the substrate
• B. Substrate binding may induce a conformational change in the enzyme, which then brings catalytic groups into proper orientation
• C. Enzyme-substrate binding induces an increase in the reaction entropy, thereby catalyzing the reaction
• D. Enzyme specificity is induced by enzyme-substrate binding