Reports of cardiac arrhythmias caused by unusually high blood levels of 2 antihistamines (terfenadine and astemizole) are best explained by

Question

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NA

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Concomitant treatment with phenobarbital

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Use of these drugs by smokers

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Use of antihistamines by persons of Asian background

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A genetic predisposition to metabolise succinylcholine slowly

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Treatment of these patients with ketoconazole

1.	Reports of cardiac arrhythmias caused by unusually high blood levels of 2 antihistamines (terfenadine and astemizole) are best explained by
A.	Concomitant treatment with phenobarbital
B.	Use of these drugs by smokers
C.	Use of antihistamines by persons of Asian background
D.	A genetic predisposition to metabolise succinylcholine slowly
E.	Treatment of these patients with ketoconazole
Answer» F.

Discussion