Regarding the pharmacokinetics of the tetracyclines

• A. Tetracyclines are 40 to 80 % bound by serum proteins
• B. Absorption is enhanced by coadministration of antacids
• C. Tetracyclines cross the blood brain barrier easily
• D. Doxycycline is excreted predominantly by the kidney
• E. Demeclocyline is a short acting tetracycline drug