Regarding the insulin receptor, which statement is INCORRECT?

• A. it is present even in cells which do not increase their glucose intake in response to insulin
• B. insulin binds to the subunit on the outer surface of the cell membrane
• C. it is a tetramer of two and two subunits
• D. the binding of insulin decreases the activity of tyrosine kinase on the intracellular end of the receptor
• E. the complex of insulin and receptor become internalised by the cell