Regarding receptor regulation

• A. Receptor down regulation occurs over hours days
• B. Receptor responses to drugs often desensitise with time this desensitisation is usually irreversible
• C. The mechanism of agonist induced desensitisation of the nicotinic Ach receptor has been worked out in detail
• D. All internalised receptors are degraded by lysosomes
• E. None of the above are correct