Regarding metastasis

• A. All carcinomas have the ability to metastasise
• B. Highly invasive carcinomas rarely metastasise
• C. Carcinomas typically spread via lymphatics compared with haematogenous spread
• D. Tumour cells develop increased cohesiveness of their cell surface in the formation of cancer cell emboli
• E. Cells involved in lymphatic dissemination release degradative enzymes