Example of a drug which has PKa > 11 is ________ – McqOptions

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1.	Example of a drug which has PKa > 11 is ________
A.	Cromolyn
B.	Imipramine
C.	Amitriptyline
D.	Mecamylamine
Answer» E.

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Example of a drug which has PKa > 11 is ________
Acids in the pKa range 2.5-7.5 are greatly affected by changes in pH making their absorption pH dependent.
If the pH of either side of the membrane is different, then the compartment whose pH favours greater ionization will have less amount of drug.
According to the pH-partition hypothesis which one of the given options doesn t govern the absorption?