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				This section includes 35 Mcqs, each offering curated multiple-choice questions to sharpen your Microbiology knowledge and support exam preparation. Choose a topic below to get started.
| 1. | Negative strand ssRNA viruses need to have a preformed replicase when they invade a mammalian cell because they | 
| A. | use it to terminate transcripts when they copy host cell mRNA | 
| B. | have to make a positive strand copy that can be translated | 
| C. | use it to modify host enzymes that are recruited for viral replication | 
| D. | none of the above | 
| Answer» C. use it to modify host enzymes that are recruited for viral replication | |
| 2. | Animal viruses with capsids displaying helical symmetry include | 
| A. | measles and mumps | 
| B. | influenza | 
| C. | rabies | 
| D. | all of these | 
| Answer» E. | |
| 3. | Icosahedral viruses are generally | 
| A. | polio viruses | 
| B. | adeno viruses | 
| C. | both (a) and (b) | 
| D. | none of these | 
| Answer» D. none of these | |
| 4. | Negri bodies are found in cells infected with | 
| A. | Paramyxoviruses | 
| B. | Vaccinia virus | 
| C. | Fowlpox virus | 
| D. | Rabies virus | 
| Answer» E. | |
| 5. | Which of the following virus is transmitted by genital route? | 
| A. | Papillomaviruses | 
| B. | Herpes simplex virus type 2 | 
| C. | Hepatitis B virus | 
| D. | All of these | 
| Answer» E. | |
| 6. | The RNA sarcoma viruses, the most strongly transforming viruses may transform which of the following cells in a culture? | 
| A. | fibroblasts | 
| B. | myoblasts | 
| C. | iris epithelial | 
| D. | all of these | 
| Answer» E. | |
| 7. | The predominant lipid substance found in the viral envelope is | 
| A. | phospholipids | 
| B. | glycolipids | 
| C. | neutral fat | 
| D. | all of these | 
| Answer» B. glycolipids | |
| 8. | The structural abnormality of cells is termed as | 
| A. | hyperplasia | 
| B. | anaplasia | 
| C. | metastasis | 
| D. | all of these | 
| Answer» C. metastasis | |
| 9. | Transfer of infection from cell to cell occurs mainly by direct transfer of virions via | 
| A. | plasmodesmata | 
| B. | cytodesmata | 
| C. | protodesmata | 
| D. | none of these | 
| Answer» B. cytodesmata | |
| 10. | Interanuclear inclusion bodies are found in cells infected with | 
| A. | Parvoviruses | 
| B. | Herpesviruses | 
| C. | Adenoviruses | 
| D. | all of these | 
| Answer» E. | |
| 11. | What is the function of positive strand in double stranded RNA viruses? | 
| A. | Synthesis of protein | 
| B. | Production of ribosomes | 
| C. | Both (a) and (b) | 
| D. | None of these | 
| Answer» B. Production of ribosomes | |
| 12. | Plant viruses penetrate host cells through transient ores called | 
| A. | ectodesmata | 
| B. | endodesmata | 
| C. | cytodesmata | 
| D. | protodesmata | 
| Answer» B. endodesmata | |
| 13. | Which of the following virus is transmitted by the respiratory route? | 
| A. | Rhinovirus | 
| B. | Coronavirus | 
| C. | Measles virus | 
| D. | All of these | 
| Answer» E. | |
| 14. | Supercoiling refers to the extra turns in the structure of ds DNA due to the action of | 
| A. | DNA gyrase | 
| B. | DNA pyrase | 
| C. | RNA gyrase | 
| D. | RNA pyrase | 
| Answer» B. DNA pyrase | |
| 15. | The transcription of the viral nucleic acid into mRNA is not necessary in case of | 
| A. | RNA viruses | 
| B. | ds DNA viruses | 
| C. | ss DNA viruses | 
| D. | all of these | 
| Answer» B. ds DNA viruses | |
| 16. | The reovirus and influenza virus contain | 
| A. | 10 different segments of dsRNA and 8 different segments of ssRNA respectively | 
| B. | 8 different segments of dsRNA and 10 different segments of ssRNA respectively | 
| C. | 5 different segments of dsRNA and 7 different segments of ssRNA respectively | 
| D. | 7 different segments of dsRNA and 5different segments of ssRNA respectively | 
| Answer» B. 8 different segments of dsRNA and 10 different segments of ssRNA respectively | |
| 17. | The microbes which are most likely to be completely dependent on a plant or animal host are | 
| A. | viruses | 
| B. | bacteria | 
| C. | fungi | 
| D. | algae | 
| Answer» B. bacteria | |
| 18. | The two major components of viruses are | 
| A. | fat and protein | 
| B. | nucleic acid and protein | 
| C. | carbohydrate and nucleic acid | 
| D. | fat and carbohydrate | 
| Answer» C. carbohydrate and nucleic acid | |
| 19. | The penetration of animal viruses into attached cells occur by mechanisms consisting of engulfment of whole virions by the cells in a phagocytic process called | 
| A. | vitropexis | 
| B. | viropexis | 
| C. | ectodesmata | 
| D. | vivopexis | 
| Answer» C. ectodesmata | |
| 20. | West Nile virus can cause a disease in human beings that may be transmitted from an infected bird to a person by a mosquito. This is an example of | 
| A. | endogenous infection | 
| B. | fomite borne disease | 
| C. | arthropod borne disease | 
| D. | nosocomial infection | 
| Answer» D. nosocomial infection | |
| 21. | Influenza virus undergoes antigenic shift resulting in major antigenic changes by which of the following mechanisms? | 
| A. | Somatic recombination of heavy and light chains | 
| B. | Expression of several different capsule types | 
| C. | Changing the receptor binding canyon that docks with the host receptor | 
| D. | Reassortment of RNA segments from different influenza viruses | 
| Answer» E. | |
| 22. | The nucleocapsid is covered by an outer membrane like structure called | 
| A. | envelope | 
| B. | covering | 
| C. | membronocapsid | 
| D. | all of these | 
| Answer» B. covering | |
| 23. | Which type of interferon is produced by virus-infected cells? | 
| A. | |
| B. | |
| C. | Both (a) and (b) | 
| D. | None of these | 
| Answer» D. None of these | |
| 24. | Fluorescence microscopy can be used for the diagnosis of | 
| A. | Subacute sclerosing panencephalitis | 
| B. | Herpes simplex encephalitis | 
| C. | Rabies | 
| D. | All of these | 
| Answer» E. | |
| 25. | Viral matrix proteins are | 
| A. | exposed on the surface of the virus | 
| B. | found mainly on naked viruses | 
| C. | anchor the envelope of enveloped viruses | 
| D. | part of the nucleoprotein core of viruses | 
| Answer» D. part of the nucleoprotein core of viruses | |
| 26. | Which of the following reflects the correct order of events that take place during the multiplication of a virus? | 
| A. | Attachment, penetration, maturation, biosynthesis, release | 
| B. | Penetration, attachment, biosynthesis, maturation, release | 
| C. | Attachment, penetration, biosynthesis, maturation, release | 
| D. | Attachment, release, biosynthesis, maturation, penetration | 
| Answer» D. Attachment, release, biosynthesis, maturation, penetration | |
| 27. | What can be coated to the plastic dish if an ELISA is performed to directly detect polio virus? | 
| A. | Patient serum | 
| B. | Anti-polio antibody | 
| C. | Polio capsid protein | 
| D. | Colored substrate | 
| Answer» C. Polio capsid protein | |
| 28. | What does the positive strand in double stranded RNA viruses stands for? | 
| A. | rRNA | 
| B. | tRNA | 
| C. | mRNA | 
| D. | None of these | 
| Answer» D. None of these | |
| 29. | Which of the following characteristics would not be used to classify viruses? | 
| A. | Type of cell wall structure | 
| B. | Type of nucleic acid | 
| C. | Presence of an envelope | 
| D. | Symmetry | 
| Answer» B. Type of nucleic acid | |
| 30. | Intracytoplasmic inclusion bodies are found in cells infected with | 
| A. | Rabies virus | 
| B. | Vaccinia virus | 
| C. | Fowlpox virus | 
| D. | all of these | 
| Answer» E. | |
| 31. | Which type of interferon is produced by T lymphocytes? | 
| A. | |
| B. | |
| C. | |
| D. | and | 
| Answer» D. and | |
| 32. | Viropexis takes place in the phagocytic vacuoles and is due to the action of enzymes | 
| A. | DNA gyrase | 
| B. | lysosomal protease | 
| C. | lysosomal lipase | 
| D. | all of these | 
| Answer» C. lysosomal lipase | |
| 33. | The uncontrolled proliferation of cells is termed as | 
| A. | hyperplasia | 
| B. | anaplasia | 
| C. | metastasis | 
| D. | all of these | 
| Answer» B. anaplasia | |
| 34. | The tissue structure deteriorates as the virus multiplies. This deterioration is called | 
| A. | aneuploidy | 
| B. | protopathic effect | 
| C. | cytopathic effect | 
| D. | none of these | 
| Answer» D. none of these | |
| 35. | Mumps vaccine is prepared from the cultures of | 
| A. | chick fibroblasts | 
| B. | African green monkey cells | 
| C. | healthy calves | 
| D. | sheep | 
| Answer» B. African green monkey cells | |