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This section includes 35 Mcqs, each offering curated multiple-choice questions to sharpen your Microbiology knowledge and support exam preparation. Choose a topic below to get started.
| 1. |
Negative strand ssRNA viruses need to have a preformed replicase when they invade a mammalian cell because they |
| A. | use it to terminate transcripts when they copy host cell mRNA |
| B. | have to make a positive strand copy that can be translated |
| C. | use it to modify host enzymes that are recruited for viral replication |
| D. | none of the above |
| Answer» C. use it to modify host enzymes that are recruited for viral replication | |
| 2. |
Animal viruses with capsids displaying helical symmetry include |
| A. | measles and mumps |
| B. | influenza |
| C. | rabies |
| D. | all of these |
| Answer» E. | |
| 3. |
Icosahedral viruses are generally |
| A. | polio viruses |
| B. | adeno viruses |
| C. | both (a) and (b) |
| D. | none of these |
| Answer» D. none of these | |
| 4. |
Negri bodies are found in cells infected with |
| A. | Paramyxoviruses |
| B. | Vaccinia virus |
| C. | Fowlpox virus |
| D. | Rabies virus |
| Answer» E. | |
| 5. |
Which of the following virus is transmitted by genital route? |
| A. | Papillomaviruses |
| B. | Herpes simplex virus type 2 |
| C. | Hepatitis B virus |
| D. | All of these |
| Answer» E. | |
| 6. |
The RNA sarcoma viruses, the most strongly transforming viruses may transform which of the following cells in a culture? |
| A. | fibroblasts |
| B. | myoblasts |
| C. | iris epithelial |
| D. | all of these |
| Answer» E. | |
| 7. |
The predominant lipid substance found in the viral envelope is |
| A. | phospholipids |
| B. | glycolipids |
| C. | neutral fat |
| D. | all of these |
| Answer» B. glycolipids | |
| 8. |
The structural abnormality of cells is termed as |
| A. | hyperplasia |
| B. | anaplasia |
| C. | metastasis |
| D. | all of these |
| Answer» C. metastasis | |
| 9. |
Transfer of infection from cell to cell occurs mainly by direct transfer of virions via |
| A. | plasmodesmata |
| B. | cytodesmata |
| C. | protodesmata |
| D. | none of these |
| Answer» B. cytodesmata | |
| 10. |
Interanuclear inclusion bodies are found in cells infected with |
| A. | Parvoviruses |
| B. | Herpesviruses |
| C. | Adenoviruses |
| D. | all of these |
| Answer» E. | |
| 11. |
What is the function of positive strand in double stranded RNA viruses? |
| A. | Synthesis of protein |
| B. | Production of ribosomes |
| C. | Both (a) and (b) |
| D. | None of these |
| Answer» B. Production of ribosomes | |
| 12. |
Plant viruses penetrate host cells through transient ores called |
| A. | ectodesmata |
| B. | endodesmata |
| C. | cytodesmata |
| D. | protodesmata |
| Answer» B. endodesmata | |
| 13. |
Which of the following virus is transmitted by the respiratory route? |
| A. | Rhinovirus |
| B. | Coronavirus |
| C. | Measles virus |
| D. | All of these |
| Answer» E. | |
| 14. |
Supercoiling refers to the extra turns in the structure of ds DNA due to the action of |
| A. | DNA gyrase |
| B. | DNA pyrase |
| C. | RNA gyrase |
| D. | RNA pyrase |
| Answer» B. DNA pyrase | |
| 15. |
The transcription of the viral nucleic acid into mRNA is not necessary in case of |
| A. | RNA viruses |
| B. | ds DNA viruses |
| C. | ss DNA viruses |
| D. | all of these |
| Answer» B. ds DNA viruses | |
| 16. |
The reovirus and influenza virus contain |
| A. | 10 different segments of dsRNA and 8 different segments of ssRNA respectively |
| B. | 8 different segments of dsRNA and 10 different segments of ssRNA respectively |
| C. | 5 different segments of dsRNA and 7 different segments of ssRNA respectively |
| D. | 7 different segments of dsRNA and 5different segments of ssRNA respectively |
| Answer» B. 8 different segments of dsRNA and 10 different segments of ssRNA respectively | |
| 17. |
The microbes which are most likely to be completely dependent on a plant or animal host are |
| A. | viruses |
| B. | bacteria |
| C. | fungi |
| D. | algae |
| Answer» B. bacteria | |
| 18. |
The two major components of viruses are |
| A. | fat and protein |
| B. | nucleic acid and protein |
| C. | carbohydrate and nucleic acid |
| D. | fat and carbohydrate |
| Answer» C. carbohydrate and nucleic acid | |
| 19. |
The penetration of animal viruses into attached cells occur by mechanisms consisting of engulfment of whole virions by the cells in a phagocytic process called |
| A. | vitropexis |
| B. | viropexis |
| C. | ectodesmata |
| D. | vivopexis |
| Answer» C. ectodesmata | |
| 20. |
West Nile virus can cause a disease in human beings that may be transmitted from an infected bird to a person by a mosquito. This is an example of |
| A. | endogenous infection |
| B. | fomite borne disease |
| C. | arthropod borne disease |
| D. | nosocomial infection |
| Answer» D. nosocomial infection | |
| 21. |
Influenza virus undergoes antigenic shift resulting in major antigenic changes by which of the following mechanisms? |
| A. | Somatic recombination of heavy and light chains |
| B. | Expression of several different capsule types |
| C. | Changing the receptor binding canyon that docks with the host receptor |
| D. | Reassortment of RNA segments from different influenza viruses |
| Answer» E. | |
| 22. |
The nucleocapsid is covered by an outer membrane like structure called |
| A. | envelope |
| B. | covering |
| C. | membronocapsid |
| D. | all of these |
| Answer» B. covering | |
| 23. |
Which type of interferon is produced by virus-infected cells? |
| A. | |
| B. | |
| C. | Both (a) and (b) |
| D. | None of these |
| Answer» D. None of these | |
| 24. |
Fluorescence microscopy can be used for the diagnosis of |
| A. | Subacute sclerosing panencephalitis |
| B. | Herpes simplex encephalitis |
| C. | Rabies |
| D. | All of these |
| Answer» E. | |
| 25. |
Viral matrix proteins are |
| A. | exposed on the surface of the virus |
| B. | found mainly on naked viruses |
| C. | anchor the envelope of enveloped viruses |
| D. | part of the nucleoprotein core of viruses |
| Answer» D. part of the nucleoprotein core of viruses | |
| 26. |
Which of the following reflects the correct order of events that take place during the multiplication of a virus? |
| A. | Attachment, penetration, maturation, biosynthesis, release |
| B. | Penetration, attachment, biosynthesis, maturation, release |
| C. | Attachment, penetration, biosynthesis, maturation, release |
| D. | Attachment, release, biosynthesis, maturation, penetration |
| Answer» D. Attachment, release, biosynthesis, maturation, penetration | |
| 27. |
What can be coated to the plastic dish if an ELISA is performed to directly detect polio virus? |
| A. | Patient serum |
| B. | Anti-polio antibody |
| C. | Polio capsid protein |
| D. | Colored substrate |
| Answer» C. Polio capsid protein | |
| 28. |
What does the positive strand in double stranded RNA viruses stands for? |
| A. | rRNA |
| B. | tRNA |
| C. | mRNA |
| D. | None of these |
| Answer» D. None of these | |
| 29. |
Which of the following characteristics would not be used to classify viruses? |
| A. | Type of cell wall structure |
| B. | Type of nucleic acid |
| C. | Presence of an envelope |
| D. | Symmetry |
| Answer» B. Type of nucleic acid | |
| 30. |
Intracytoplasmic inclusion bodies are found in cells infected with |
| A. | Rabies virus |
| B. | Vaccinia virus |
| C. | Fowlpox virus |
| D. | all of these |
| Answer» E. | |
| 31. |
Which type of interferon is produced by T lymphocytes? |
| A. | |
| B. | |
| C. | |
| D. | and |
| Answer» D. and | |
| 32. |
Viropexis takes place in the phagocytic vacuoles and is due to the action of enzymes |
| A. | DNA gyrase |
| B. | lysosomal protease |
| C. | lysosomal lipase |
| D. | all of these |
| Answer» C. lysosomal lipase | |
| 33. |
The uncontrolled proliferation of cells is termed as |
| A. | hyperplasia |
| B. | anaplasia |
| C. | metastasis |
| D. | all of these |
| Answer» B. anaplasia | |
| 34. |
The tissue structure deteriorates as the virus multiplies. This deterioration is called |
| A. | aneuploidy |
| B. | protopathic effect |
| C. | cytopathic effect |
| D. | none of these |
| Answer» D. none of these | |
| 35. |
Mumps vaccine is prepared from the cultures of |
| A. | chick fibroblasts |
| B. | African green monkey cells |
| C. | healthy calves |
| D. | sheep |
| Answer» B. African green monkey cells | |