Which of the following wrong about HMM GENE?

• A. It is also an HMM-based web program
• B. It uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding features
• C. HMM prediction is unbiased toward the locked region
• D. If a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regions