Which of the following is untrue about Homology-Based Programs?

• A. They are based on the fact that exon structures and exon sequences of related species are less conserved
• B. This approach assumes that the database sequences are correct
• C. It is a reasonable assumption in light of the fact that many homologous sequences to be compared with are derived from cDNA or expressed sequence tags (ESTs) of the same species
• D. Potential coding frames in a query sequence are translated and used to align with closest protein homologs found in databases