Which of the following is false in case of the database Pfam and its algorithm?

• A. Each motif or domain is represented by an HMM profile generated from the seed alignment of a number of conserved homologous proteins
• B. Since the probability scoring mechanism is more complex in HMM than in a profile-based approach the use of HMM yields further increases in sensitivity of the database matches
• C. Pfam-B only contains sequence families not covered in Pfam
• D. The functional annotation of motifs in Pfam-A is often related to that in UNIPROT