How many arrangements can be made out of the letters of the word COMMITTEE, taken all at a time, such that the four vowels do not come together?

How many arrangements can be made out of the letters of the word CO

1.	How many arrangements can be made out of the letters of the word COMMITTEE, taken all at a time, such that the four vowels do not come together?
A.	216
B.	45360
C.	1260
D.	43200
Answer» E.