MCQOPTIONS
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				| 1. | 
                                    Changes least likely with familial colonic cancer | 
                            
| A. | APC gene mutation | 
| B. | DNA repair gene mutation | 
| C. | Chromosomal translocation | 
| D. | Microsatellite instability | 
| E. | Loss of heterozygosity for tumour suppressor genes | 
| Answer» D. Microsatellite instability | |