A 55-year-old man underwent resection of a T2 clear cell renal carcinoma. What is the most likely pathogenesis?

activating mutations of the VHL gene

up-regulated expression of HIF-controlled genes

A 55-year-old man underwent resection of a T2 clear cell renal carcino

1.	A 55-year-old man underwent resection of a T2 clear cell renal carcinoma. What is the most likely pathogenesis?
A.	activating mutations of the VHL gene
B.	MET oncogene activity
C.	mutation of p53
D.	up-regulated expression of HIF-controlled genes
E.	von Hippel Lindau syndrome
Answer» E. von Hippel Lindau syndrome

Discussion

No Comment Found

Related MCQs

A male patient presented with increasing weight loss and abdominal pain. He had a past history of Coeliac Disease, which up until now was asymptomatic on a gluten free diet. CT of the abdomen revealed a thickened loop of small bowel with a stricture and associated lymphadenopathy. A trucut of the nodes revealed a malignant neoplasm, Diagnosis is:
A 40 year old female presents with mediastinal hilar lymphadenopathy and she has recently noticed slight weight loss and a cough. Staging shows no other evidence of disease. A trucut biopsy reveals a lymphoma showing large cells with mirror image nuclei, lymphocytes, plasma cells and eosinophils. The following phenotype is seen; CD20 positive, CD3 negative, CLA positive, and CD15 positive
A 50 year old male presents with widespread lymphadenopathy. He has had recent fever and weight loss. A trucut biopsy reveals a malignant tumor with the following phenotype; Cytokeratin negative, CLA positive, CD3 positive, and CD30 positive
Which of the following equations is used to determine a positive predictive value?
A 55 year old male presents with a history of chronic dyspepsia and with recent weight loss. Investigation by gastroscopy reveals a reduction in specialised gastric glands and the presence of slender giemsa staining filaments on the mucosal surface. In addition a gastric mass is seen. This is composed of large B lymphocytes which are negative for cyclin D1 and BCL2. Monoclonality is identified.
A 28-year-old woman was found to have stage IV Burkitt s lymphoma. Her renal function was normal and a staging CT scan had shown no abnormality of the renal tract. Three days later, when she was about to start chemotherapy, she developed a temperature of 39.0 C with rigors and was treated with imipenem. Investigations (the following day):serum sodium 138 mmol/L (137 144)serum potassium 6.2 mmol/L (3.5 4.9)serum creatinine 215 mol/L (60 110)serum corrected calcium 1.60 mmol/L (2.20 2.60)serum phosphate 1.52 mmol/L (0.8 1.4)serum lactate dehydrogenase 1238 U/L (10 250)serum urate 0.69 mmol/L (0.19 0.36)What is the most likely cause of the renal impairment?
A 67-year-old man in previously good health is hospitalized because of a 2-day history of fever and diminished consciousness. The patient responds inconsistently to verbal commands. His temperature is 39.5 C (103.1 F); he has tachycardia, and his blood pressure is 80/58 mm Hg. There is no bleeding. His hemoglobin is 12.1 g/dL, leukocyte count is 29,000/ L with 80% neutrophils, and platelet count is 20,000/ L. Which of the following studies should be obtained in this patient?
A 37-year-old man is hospitalized because of fever and right-sided chest pain. He has been having fatigue and recently developed dyspnea on exertion and intermittent chills. At the age of 29 years he was diagnosed with stage III Hodgkin s disease and treated with multiagent chemotherapy and radiation therapy. A year ago, he developed mild anemia with no obvious cause. He takes thyroid hormone replacement when he remembers and has used fexofenadine as needed for allergic rhinitis for the past 5 years. On physical examination, his temperature is 38.7 C (101.7 F), pulse rate is 112/min, and blood pressure is 110/70 mmHg. There is dullness at the right lower lung and egophony. The hemoglobin is 8.5 g/dL, hematocrit is 26 %, leukocyte count is 2200/ L,and platelet count is 70,000/ L. What is the most likely diagnosis?
A 43-year-old man with severe acquired aplastic anemia has not responded to immunosuppressive agents. He remains neutropenic and transfusion-dependent for platelets and red cells. He has an HLA-identical brother who has been cleared as a donor for his planned allogeneic stem cell transplant.They are both cytomegalovirus-seronegative. Which of the following would be prevented by using irradiated cellular blood products for this patient?
A 34-year-old woman is evaluated because of progressive fatigue and recurrent attacks of abdominal pain. She weighs 61.2 kg (135 Ib). Her pulse rate is 110/min and her blood pressure is 110/70 mm Hg. She is pale, and her spleen is palpable 4 cm below the costal margin. Laboratory studies: Hemoglobin 6 g/dLHematocrit 20% Leukocyte count 2500/ L Platelet count 80,000/ L Reticulocyte count 10%Blood smear Anisocytosis and polychromatophilia Haptoglobin 0 mg/dLSerum lactate dehydrogenase 645 U/LThere is high level of hemosiderin in the urine.What is the most likely cause of this patients pancytopenia?

A 55-year-old man underwent resection of a T2 clear cell renal carcinoma. What is the most likely pathogenesis?

Discussion

No Comment Found

Related MCQs

Reply to Comment