A 30-year-old woman has a right mastectomy and axillary lymph node dissection for a carcinoma diagnosed by fine needle aspiration cytology. The histologic pattern is that of a poorly differentiated carcinoma that is negative for oestrogen and progesterone receptors, but is positive for HER2/neu. One axillary lymph node demonstrates micro- metastases. Her 32 year old sister is found to have a similar lesion. Which of the following statements regarding risk factors for this lesion is the most appropriate?

A history of late menarche is likely to be present in females in this family

Fibrocystic changes were present for many years

She had a history of exposure to hydrocarbon compounds

She has a positive antinuclear antibody test

These findings suggest a BRCA-1 mutation

A 30-year-old woman has a right mastectomy and axillary lymph node dis

1.	A 30-year-old woman has a right mastectomy and axillary lymph node dissection for a carcinoma diagnosed by fine needle aspiration cytology. The histologic pattern is that of a poorly differentiated carcinoma that is negative for oestrogen and progesterone receptors, but is positive for HER2/neu. One axillary lymph node demonstrates micro- metastases. Her 32 year old sister is found to have a similar lesion. Which of the following statements regarding risk factors for this lesion is the most appropriate?
A.	A history of late menarche is likely to be present in females in this family
B.	Fibrocystic changes were present for many years
C.	She had a history of exposure to hydrocarbon compounds
D.	She has a positive antinuclear antibody test
E.	These findings suggest a BRCA-1 mutation
Answer» F.

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